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A Book with Legs

Kathryn Paige Harden - Original Sin: On The Genetics of Vice, The Problem of Blame, And the Future of Forgiveness

A Book with Legs

Smead Capital Management

Business, Investing, Management

4.31.2K Ratings

🗓️ 16 March 2026

⏱️ 86 minutes

🧾️ Download transcript

Summary

How much of our temperament and behavior is passed through DNA, and how do we punish those whose behavior may be shaped by genetic forces outside of their control?

These concepts are explored in the latest episode of A Book with Legs, where Smead Capital Management CEO and Portfolio Manager Cole Smead is joined by professor, scientist, and author Kathryn Paige Harden to discuss her book, “Original Sin: On the Genetics of Vice, the Problem of Blame, and the Future of Forgiveness.” Cole and Kathryn discuss the ideas of right, wrong, and sin, and how much our genetics are to blame for our actions. The two also analyze findings from studies led by Paige and the mental frameworks of some of history’s greatest theological minds to guide their discussion

Harden is a professor of psychology at the University of Texas, where she directs the Developmental Behavior Genetics lab. She conducts research on how genes and environments combine to shape children's mental and physical health. She is the author of over 150 scientific publications and two books: The Genetic Lottery and Original Sin. Purchase a copy of “Original Sin: On the Genetics of Vice, the Problem of Blame, and the Future of Forgiveness” here: https://www.penguinrandomhouse.com/books/714593/original-sin-by-kathryn-paige-harden/

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Transcript

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0:00.0

You're listening to A Book with Legs, a podcast presented by Smead Capital Management.

0:07.9

At Smead Capital Management, we advise investors who play the long game.

0:12.3

You can learn more at Smeadcap.com or by calling your financial advisor.

0:23.8

Welcome to a book with legs podcast.

0:28.0

I'm Cole Smead, CEO, and portfolio manager here at Smead Capital Management.

0:33.3

At our firm, we are readers, and we believe in the power of books to help shape informed investors.

0:36.7

In this podcast, we speak to great authors about their writings.

0:41.3

The late great Charlie Munger prescribed using multiple mental models and analysis.

0:46.1

We analyze their work through the lens of business, markets, and people.

0:57.2

In this episode, we will discuss the depths of our humanness, our being, our physical makeup, our emotional makeup, and possibly what I might argue is our spiritual makeup. Joining me to discuss her recently published book,

1:02.3

Original Sin, on the genetics of vice, the problem of blame and the future of forgiveness

1:07.5

is Catherine Page Harden.

1:12.6

I'll refer to her as Paige.

1:17.9

Page is a professor of psychology at the University of Texas, Austin, Hookham Horns.

1:22.2

She received her PhD in Clinical Psychology from the University of Virginia and completed her clinical internship at McLean Hospital, Harvard Medical School. She has been honored by

1:28.6

the American Psychological Association for her distinguished scientific contributions in the fields

1:33.4

of genetics and human individual differences. She has published one other book, I would note,

1:38.9

the genetic lottery, which came out in 2021. More importantly, Ms. Hardin seems to be included in the deeply intellectual community

1:47.5

that treasures the infamous Pinky and the Brain cartoons from my childhood.

1:51.7

Paige, thanks for joining me today.

1:53.2

Oh, thanks for having me.

1:54.7

You were the first introducer to bring up Pinky and the Brain that is a niche reference,

...

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