Journal Review in Thoracic Surgery: The ESOPEC Trial
Behind The Knife: The Surgery Podcast
Behind The Knife: The Surgery Podcast
4.8 • 1.4K Ratings
🗓️ 17 April 2025
⏱️ 25 minutes
🧾️ Download transcript
Summary
Learning Objectives:
-Discuss the patient population in the ESOPEC trial
-Discuss the main differences between the ESOPEC trial and the CROSS trial
-Describe the main drawbacks between FLOT and the CROSS regimen.
Hosts:
Chloe Hanson MD, Brian Louie MD, and Peter White MD
Referenced Material
https://www.nejm.org/doi/full/10.1056/NEJMoa2409408
Hoeppner J, Brunner T, Schmoor C, Bronsert P, Kulemann B, Claus R, Utzolino S, Izbicki JR, Gockel I, Gerdes B, Ghadimi M, Reichert B, Lock JF, Bruns C, Reitsamer E, Schmeding M, Benedix F, Keck T, Folprecht G, Thuss-Patience P, Neumann UP, Pascher A, Imhof D, Daum S, Strieder T, Krautz C, Zimmermann S, Werner J, Mahlberg R, Illerhaus G, Grimminger P, Lordick F. Perioperative Chemotherapy or Preoperative Chemoradiotherapy in Esophageal Cancer. N Engl J Med. 2025 Jan 23;392(4):323-335. doi: 10.1056/NEJMoa2409408. PMID: 39842010.
https://www.nejm.org/doi/full/10.1056/NEJMoa1112088
van Hagen P, Hulshof MC, van Lanschot JJ, Steyerberg EW, van Berge Henegouwen MI, Wijnhoven BP, Richel DJ, Nieuwenhuijzen GA, Hospers GA, Bonenkamp JJ, Cuesta MA, Blaisse RJ, Busch OR, ten Kate FJ, Creemers GJ, Punt CJ, Plukker JT, Verheul HM, Spillenaar Bilgen EJ, van Dekken H, van der Sangen MJ, Rozema T, Biermann K, Beukema JC, Piet AH, van Rij CM, Reinders JG, Tilanus HW, van der Gaast A; CROSS Group. Preoperative chemoradiotherapy for esophageal or junctional cancer. N Engl J Med. 2012 May 31;366(22):2074-84. doi: 10.1056/NEJMoa1112088. PMID: 22646630.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)32557-1/abstract
Al-Batran SE, Homann N, Pauligk C, Goetze TO, Meiler J, Kasper S, Kopp HG, Mayer F, Haag GM, Luley K, Lindig U, Schmiegel W, Pohl M, Stoehlmacher J, Folprecht G, Probst S, Prasnikar N, Fischbach W, Mahlberg R, Trojan J, Koenigsmann M, Martens UM, Thuss-Patience P, Egger M, Block A, Heinemann V, Illerhaus G, Moehler M, Schenk M, Kullmann F, Behringer DM, Heike M, Pink D, Teschendorf C, Löhr C, Bernhard H, Schuch G, Rethwisch V, von Weikersthal LF, Hartmann JT, Kneba M, Daum S, Schulmann K, Weniger J, Belle S, Gaiser T, Oduncu FS, Güntner M, Hozaeel W, Reichart A, Jäger E, Kraus T, Mönig S, Bechstein WO, Schuler M, Schmalenberg H, Hofheinz RD; FLOT4-AIO Investigators. Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial. Lancet. 2019 May 11;393(10184):1948-1957. doi: 10.1016/S0140-6736(18)32557-1. Epub 2019 Apr 11. PMID: 30982686.
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Transcript
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| 0:00.0 | Behind the Night, the Surgery Podcast, relevant and engaging content designed to help you dominate the day. Calling all Surgical Education Junkies. |
| 0:26.6 | Behind the Knife is looking to add new fellows to our team this year. |
| 0:29.6 | We are thrilled to be adding these positions as we've got big plans for the future, and we want you to be a part of them. |
| 0:35.9 | We're working on countless projects that will make a real impact on surgical education, |
| 0:40.0 | including a modern, engaging general surgery curriculum, and slick new videos. |
| 0:45.4 | We're looking for enterprising and surgical residents to take the bowl by the horns |
| 0:48.9 | and build something new and exciting. |
| 0:51.9 | Fellows will benefit from ample support from the behind-the-knife team, |
| 0:54.8 | including the use of our brand new digital education platform and access to all of our |
| 0:59.7 | resources like illustrators, video editing, social media, and more. |
| 1:04.4 | Get your name out there and build your CV by being part of the number one |
| 1:07.6 | surgery education platform in the world. |
| 1:10.0 | We're offering a two-year fellowship |
| 1:12.0 | starting in July 2025 and ending in June 2027. Only residents beginning their two-year |
| 1:18.3 | academic development time will be considered, and the residents' institutions and mentors |
| 1:22.8 | must approve of this fellowship. Check out the show notes for the application link. All applications are due |
| 1:28.7 | April 20th. Again, all applications are due on April 20th. Dominate the day. Hi, and welcome to |
| 1:37.3 | another journal review in thoracic surgery with your Swedish thoracic surgery team. I'm Chloe Hansen. I'm a |
| 1:43.1 | third year general surgery resident currently in my research year here at Swedish,. I'm Chloe Hansen. I'm a third year journal surgery resident currently |
| 1:44.9 | in my research year here at Swedish, and I'm joined by my extremely esteemed attendings, Dr. Brian |
| 1:50.3 | Louis and Dr. Peter White. How do you do? Hello. Today will be the last Swedish thoracic |
| 1:57.0 | surgery podcast contribution to Behind the Knife. For this journal club, we are discussing the highly awaited ESOPEC trial, published in January |
... |
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