Journal Review in Colorectal Surgery: Total Neoadjuvant Therapy (TNT) for Rectal Cancer

Behind The Knife: The Surgery Podcast

Science, Health & Fitness, Medicine, Education

4.8 • 1.4K Ratings

🗓️ 8 November 2021

⏱️ 32 minutes

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Summary

Adjuvant? Neoadjuvant? Short course? Long course? The treatment of rectal cancer treatment has come a long way. Tune in to learn more about Total Neoadjuvant Therapy (TNT) and the mysterious HOLY PLANE.

Learning Objectives:

1. Describe the rationale for Total Neoadjuvant Therapy (TNT) for rectal cancer
2. Review the history of chemo and radiation therapy in treatment of rectal cancer
3. Describe total mesorectal excision

References

Bahadoer RR, Dijkstra EA, van Etten B et al. Short-course radiotherapy followed by chemotherapy before total mesorectal excision (TME) versus preoperative chemoradiotherapy, TME, and optional adjuvant chemotherapy in locally advanced rectal cancer (RAPIDO): a randomised, open-label, phase 3 trial. Lancet Oncol. 2021 Jan;22(1):29-42. doi: 10.1016/S1470-2045(20)30555-6. Epub 2020 Dec 7
https://doi.org/10.1016/S1470-2045(20)30555-6

Fokas E, Allgäuer M, Polat B et al. Randomized Phase II Trial of Chemoradiotherapy Plus Induction or Consolidation Chemotherapy as Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer: CAO/ARO/AIO-12. J Clin Oncol. 2019 Dec 1;37(34):3212-3222. doi: 10.1200/JCO.19.00308
https://ascopubs.org/doi/10.1200/JCO.19.00308

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Transcript

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0:00.0	behind the knife the surgery podcast where we take a behind the scenes intimate look at surgery
0:06.0	from leaders in the field.
0:21.4	All right, hello to all the behind the knife listeners. The Leahy team is back.
0:26.4	Our second episode, our first journal club session. So once again, I'm honored to be joined
0:30.8	by Dr. Tess Alette and Dr. Peter Marcello. Hey, John, happy to be back at Leahy.
0:36.5	Yeah, John, I'm really excited to be back. I'm looking forward to the journal club.
0:40.1	It's a bit different. We had a lot of fun with the first episode and I think this will be just as good.
0:45.5	Awesome. So before we get into the meat of the session, a couple of important updates. So first of all,
0:51.3	congratulations to Tess who graduated from colon and rectal surgery residency training.
0:56.9	Tess, what are you up to these days? So I'm over at UMass doing a clinical associate year,
1:03.8	doing a lot of really awesome things and it's been a great first few months as an attending.
1:11.3	Yeah, certainly you get those first weekend jitters. I did get a call from Tess with a few cases
1:16.7	that were of interest the first weekend. You got a couple calls. Yeah, I got a couple. So
1:21.6	wait a minute. So while you're over there, are you saying anything different with Justin
1:24.8	Michael and the crew there? What they're doing? Yeah, we're doing a do a lot of straight lap and a lot
1:30.8	of TATME. So that's been really awesome to to learn that new new skill. So a lot of TATME,
1:40.3	which has been great. But don't forget to tell them about Leahy now what we do here.
1:45.3	Obviously, obviously. All right, John, get us rolling.
1:48.8	Great. Well, congratulations once again. So we are in fact adapting to life without you
1:53.9	here at Tess. We're excited. We have this year's colorectal fellows, Dr. Bobby Kuseko is coming
1:58.2	to us from Thomas Jefferson in Philadelphia and then Dr. Raghavan Sidharth and he came to us from
2:04.0	OHSU. So we're going to be talking about a couple journal articles related to rectal cancer,
	...

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