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Mayim Bialik's Breakdown

Johann Hari: The Truth About Depression, GLP-1s and ADHD & Why Our Biology Is Not To Blame

Mayim Bialik's Breakdown

Mayim Bialik

Comedy, Health & Fitness, Mental Health

4.85.9K Ratings

🗓️ 29 July 2025

⏱️ 56 minutes

🧾️ Download transcript

Summary

Is Big Pharma really healing us — or profiting from keeping us sick?


NYT best-selling author Johann Hari (Stolen Focus, Lost Connections, Chasing the Scream, Magic Pill) returns with a powerful breakdown of the real causes of depression, anxiety, and the global attention crisis.


Johann Hari reveals why only 2 of the 9 causes of depression are biological, exposing how Big Pharma, social media addiction, and modern lifestyle traps are fueling mental health issues. He dives into the dark rise of GLP-1 drugs (like Ozempic) and society’s toxic beauty obsession, while uncovering the overlooked role of sleep, community, and social connection in healing.


Hari shares his personal experience with antidepressants, and explores how childhood shame and trauma drive addiction, weight gain, and despair. You’ll learn why even pets are being diagnosed with ADHD, what Silicon Valley insiders confessed about attention-hacking technology, and how our loss of focus is sabotaging relationships, careers, and democracy itself.


If you’re ready to challenge the myths of mental health, regain your focus, and take back control of your mind, don’t miss this eye-opening conversation with Johann Hari.


Check out all of Johann Hari's Books: https://johannhari.com/

Our first episode with Johann Hari: https://youtu.be/JKFuI96biDU

Follow us on Substack for Exclusive Bonus Content: ⁠⁠⁠https://bialikbreakdown.substack.com/⁠⁠⁠


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See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Transcript

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0:00.0

My MB Alex breakdown is supported by Helix sleep. Bring is in the air and so are all of the allergens that come with it. Spring allergens means you need more sleep, but there are a ton of factors that can prevent us from getting a good night's rest. Night sweats, back pain, feeling the person next to you when they roll over a million times. We were so excited to hear that Helix wanted to partner with us. I've had my Helix mattress for about five years now and I have been sleeping so much better. Jonathan and also our kids love their Helix mattresses and all of those issues, night sweats, back pain, motion transfer, those things are significantly better with a Helix mattress. Helix delivers your mattress right to your door, which is so much fun with free shipping in the US. They have a 120 night sleep trial and limited lifetime warranty plus.

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1:02.6

That's helixleap.com slash breakdown

1:04.9

for 27% off site wide. That's helixleap.com slash breakdown

1:05.0

for 27% off site wide. helixleap.com slash breakdown. Pain was kind of leaking out of me and I couldn't control it. My doctor said some people are just lacking a chemical in their brain called serotonin. All we need to do is give you this drug you'll be fine. And I was taken higher and higher doses until for 13 years I took the maximum possible dose and still felt like **** it.

1:25.9

People want a simple story.

1:27.9

They want one thing to be wrong that involves one medication to fix it. The factors causing depression and anxiety and our attention problems are really **** big. Human pain is not a malfunction. Human pain is a signal. There isn't even any evidence that people with depression have lower serotonin. It's agony, it's the worst thing I've ever experienced to be depressed, but it's telling you something really important. And if we treat it as a malfunction, it's an inaccurate map of pain. This is a system built entirely around topic and entirely around these dysfunctional incentives. I'm constantly amazed that Americans don't burn down the system healthcare in this country. If you're depressed, if you're anxious, you're not weak, you're not crazy, you're not a machine with broken parts, you're a human being with unmet needs. Hi, I'm Mayama Yalik. I'm Jonathan Cohen. And welcome to our breakdown. We're going deep into the incentive structure that is keeping us sick and distracted today. Depression, anxiety, ADHD. If you think that you're experiencing any of these or know someone who is, there are systems that play that may be increasing the likelihood and we are going to talk about what to really do about them. So many of us think that we know what depression comes from. So many of us think that we understand why we're anxious. So many of us think we understand the new framework around ADHD and neurodivergence. Our guest today is going to talk about how so many of the things that we have been told to believe about how we become sick and how we can

3:05.9

get better are actually distortions of a system that is designed to tell a completely different story than the one that most of us are experiencing. Yo Han Hari is an incredible thinker and author and researcher. His book Chasing the Scream is what some people say is the best book about addiction, lost connections uncover uncovering the real causes of depression is, I think, one of the finest books written about the mental health crisis in this country. And stolen focus, why you can't pay attention. We'll focus a lot on this. Why is everybody being prescribed medication? Why is everyone saying that's the solution? There's nothing else I can do. I'm just going to go on anti-depressants. I'm just going to take this stimulant and everything's going to be fine. Why do those medications not work? And what are the things you can do to actually get to the root of what is leading to what really is an epidemic of mental health complexity in this country? We've spoken to Johan Hari once before. His book Magic Pill was, I believe, the first written about OZzempik. He discusses his experience with it and we'll touch on that a little bit today. We're so excited to welcome in person Johan Hari to the breakdown. Break it down. I am like ridiculously happy to be here. We're so excited to have you in person. And if you didn't hear our first episode, we recommend that people listen to it.

4:26.0

Mainly because it was the peak moment of my life and my existence on my path. Tell us what was so special for you about your first time with us. You know why, and I'll begin to cry. If I, you say it because I'll cry. Deep and left field, this one came out. Johann is a huge beaches fan. Deep cut. I was very deep cut. When I was 12, I played the young vet midler in the movie Beaches.

4:46.3

It was not my first-

4:46.8

You were still playing her.

4:47.6

It was not my first role, but it was kind of the thing that led to really the entirety of my life and careers. We know it was after that that I did blossom, but yeah, you were a huge beachist. I literally know, I almost literally know it by heart. How many times have you seen times have you seen beaches like so between the ages of 12 and 15 I think I watched it with my best friend Like twice a week like every single week. Why would you do that to yourself? It's very sad and it's it's tragic and We'd like to realize that I profoundly misunderstood the plot of bitches.

5:25.0

Because when I then didn't watch it for many, many years until like maybe most people think Barbara Hershey's character had cancer. She did not know she has, oh, I know the name of it. It's what's it called? It's a brain disease. No, she had a heart. It was a heart thing. Cardio myopathy is the name of the broth. Okay. Yes. Yes. Why did you miss the plot of the whole movie?

5:45.5

So, I was very familiar with a lot of addiction and insanity

5:49.0

and a lot of narcissism. And I now realize that the arc of beaches is that CC Bloom, your character, Betmiddler's character, is very narcissistic at the start. Enough about me. What do you think about that? Exactly. And the movie is part of the story of C.C. Blume overcoming her narcissism through this

6:07.1

friendship with Hillary, right?

...

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