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Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Isavuconazole Pharmacology

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5716 Ratings

🗓️ 11 August 2022

⏱️ 13 minutes

🧾️ Download transcript

Summary

Isavuconazole is an azole antifungal that can be used for various fungal infections.



In this episode, I discuss isavuconazole pharmacology, adverse effect, drug interactions, and pharmacokinetics.



Isavuconazole is interestingly associated with QT shortening which is different from most azole antifungals that cause QT prolongation.



Oral bioavailability of isavuconazole is nearly 100% so dose conversions between IV and oral are typically not difficult to navigate.

Transcript

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0:00.0

Hey all, welcome back to the Real Life Pharmacology podcast. I'm your host, pharmacist,

0:04.2

Derek Christensen. Thank you so much for listening today. So always go check out real life pharmacology.com.

0:11.0

Simply subscribing by email, we'll get you a top 200 study guide. It's a 31 page PDF.

0:19.1

Great if you need a refresher out in practice.

0:21.8

A great useful tool if you're taking pharmacology classes, board exams.

0:27.6

A great tool for many clinicians, health care professionals, to utilize and benefit from.

0:34.5

So again, go take advantage of that. Real Life Pharmacology.com.

0:38.8

One other note I wanted to mention. I get occasional mentions. Can you do this podcast? Can you do

0:44.5

that podcast on a specific drug? Please go to real life pharmacology.com. Go under the podcast tab,

0:54.1

and you should be able to search the specific drug you're looking for.

0:58.9

I've also got them categorized if you look at the right-hand sidebar if you're viewing from a

1:05.6

laptop computer.

1:07.8

Sometimes they don't pull into all the podcast platforms, but I've done hundreds of podcasts at this point.

1:17.3

So definitely go check it out if you're thinking of a fairly common drug that's being used.

1:24.6

Odds are likely I've already done that podcast. So again, you can find all

1:29.4

those at real-life pharmacology.com. All right, the drug of the day today is isavukonazole.

1:37.0

Brand name of this medication is Cresemba, and this drug is under the class of azal antifungals.

1:46.7

But there definitely are some important differences with this agent that I think you definitely

1:53.6

need to be aware of for sure.

1:56.0

So first off, you may see the drug stated or its salt form stated instead of isofuconazole.

2:06.6

You may see isovuconazoneum sulfate as the actual drug.

2:13.6

And that's the reason for that is it is a pro-drug. So it's immediately cleaved into the active drug. And that's the reason for that is it is a pro-drug. So it's immediately cleaved into the

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