Is This Right for Me? Melatonin: The Truth About Dose, Timing, and Sleep
Commune with Jeff Krasno
Commune Media
4.5 • 673 Ratings
🗓️ 28 April 2026
⏱️ 46 minutes
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| 0:00.0 | Your sleep-wake cycle runs on two primary hormones, the yang and the yin of your daily rhythm. |
| 0:07.9 | The first peaks at dawn, talking about cortisol. |
| 0:11.0 | It rises in the hour before you wake, lifting core body temperature, increasing alertness, |
| 0:16.3 | and preparing your cardiovascular system for the day ahead. |
| 0:20.3 | The second peaks at dusk, as light fades and |
| 0:24.0 | cortisol falls, melatonin rises. It signals to your brain and your body that nighttime has arrived |
| 0:31.9 | and it's time to wind down. These two hormones work in harmonic counter-opposition, when one rises, the other falls, |
| 0:40.0 | and your circadian rhythm depends on both of them doing their jobs at the right time. |
| 0:46.7 | So when that timing breaks down, for example, when cortisol is elevated too late into the night, |
| 0:52.4 | melatonin blunted or delayed. Sleep suffers, stress, |
| 0:57.0 | compounds, memory degrades, and overnight physiological repair gets disrupted. This episode |
| 1:04.4 | focuses on the dark side of that relationship. Melatonin, a molecule that has existed in living organisms for roughly three billion |
| 1:13.6 | years that your body produces indogynously every night in a quantity smaller than a grain |
| 1:20.7 | of salt, and that the U.S. supplement industry now sells in doses up to 30 times that amount. Welcome to the Commune podcast. My name is |
| 1:31.6 | Jeff Krasno. And welcome to a series that I started about a month ago called Is This Right for Me? |
| 1:37.8 | Where we slow down on the protocols, supplements, therapies, and treatments flooding your |
| 1:43.2 | Instagram feed. And we ask the only |
| 1:45.6 | question that really actually matters, not whether something is fashionable, but whether it is |
| 1:51.0 | right for you. So I've done a reading and quite a bit of research. And I'll tell you where it led |
| 1:57.7 | and you decide. |
| 2:08.7 | So every night when the light fades and darkness emerges, a molecule stirs inside of you. And life has been making this exact molecule atom for atom structurally unchanged for something approaching 3 billion years. It was made in bacteria before there |
| 2:20.6 | were cells with nuclei, before there was anything even close to having eyes. Long before its sleep |
... |
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