Is longevity science overhyped? | Professor Charles Brenner, PhD

The Proof with Simon Hill

Simon Hill

Nutrition, Health & Fitness, Self-improvement, Education

4.9 • 2.9K Ratings

🗓️ 31 July 2023

⏱️ 140 minutes

🔗️ Recording | iTunes | RSS

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Summary

Episode #272. In the quest for an extended lifespan, has science been led astray? Join me as I sit down with Professor Charles Brenner, a leading global expert in NAD biology, to examine the longevity field's claims and controversies. From debunking common beliefs to questioning high-profile opinions, Dr Brenner delivers a refreshingly candid perspective on the science of aging. Tune in to explore why he believes there's no “cure” for aging, the limitations of animal studies, and what the future might hold for this complex field. Specifically, we discuss: Intro (00:00) Do we have the genes to live beyond 120 years? (3:54) The genetics of extreme longevity (14:18) Longevity in the animal kingdom (18:26) Why do we age, and the realities of extending lifespan (31:22) How long can we live? (39:01) NAD coenzymes and DNA repair (43:49) "Anti-ageing" products (55:17) Conflicts of interest and the integrity of scientific claims (1:01:08) Discovering nicotinamide riboside (NR) (vitamin B3) (1:03:19) Sirtuins as anti-ageing genes (1:09:22) A rebuttal to Drs. David Sinclair and Lenny Guarente (1:19:13) Seeking consensus on the study of human longevity (1:32:57) The information theory of aging (1:43:19) Dr. Charles Brenner's theory of ageing (2:00:28) How to age better (2:03:30) Dr. Brenner on the quality of life (2:09:05) NR supplementation (2:10:09) Moving beyond Yamanaka factors (2:15:02) Outro (2:18:45) Connect with Dr Charles Brenner on Twitter, and visit his website, https://www.brennerlab.net/, for more. Optimise your health with InsideTracker’s biomarker analysis. Get exclusive access to InsideTracker’s new ApoB test, and a significant discount at insidetracker.com/simon. Enjoy, friends. Simon Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Transcript

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0:35.9	Dr. German Newman, nutritionist Jacqueline Orwell, and naturopath Dr. Julie Chen.
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0:57.0	proof.com forward slash friends.
0:59.8	That's the proof.com forward slash friends and follow the link to Emil's website.
1:08.3	It's actually misleading to say that these growth hormone genes are, quote, longevity
1:15.0	genes because really they're growth factor genes.
1:19.2	They literally encode growth factors.
1:21.9	It's the loss of growth factor signaling that gives you an extraordinarily extended lifespan
1:33.6	with no fertility.
1:35.4	And actually the most outstanding, amazing example of an animal that outlives her reproductive
1:49.4	capacity is the human female.
1:53.8	Welcome back to another episode of the proof.
1:56.2	I'm Simon Hill, your show host, and today's guest is Professor Charles Brenner.
2:01.7	Charles is a leading global expert in the biology, chemistry, and medicine of NAD, the central
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