Hey, we are live. It's Dr. J. In the House with Evan Brand. Today we're going to be talking about

molecular mimicry, intestinal permeability, and how that can increase your risk for

autoimmune conditions. Again, today, this is not medical advice. We're just trying to look at

root underlying physiological imbalances and how that could maybe downstream increase your chance

of autoimmune conditions and inflammation. So we're going to just look at some of the literature or look at some of the underlying mechanisms like molecular mimicry and talk about how that can increase your chance of autoimmune issues. Evan, how are we doing today, man? Doing good, doing good. Man, I wanted to know, when did you figure out you had Hashimoto's? Did you run antibody screening at one point?

Yeah. And you felt off or what happened? No, I was actually doing really good with my health overall. I have a mild

elevation and TPO and thyroid globulin and I always felt off with gluten and things like

that and I had some gut issues at one point, you know, fungal overgrowth, H. Pylori, other things.

And so I knew the gut was so important because when you start with functional medicine

training, you understand that 80% of the immune

systems in the gut. So any gut stress can impact the immune system. Anytime you have poor digestion,

you're going to have some gut stress. Now, the problem is you are 8x likely to have a gut

issue and not have a gut symptom, meaning you have brain fog, you have fatigue,

you have mood issues, and the gut. That's why we have to look at the gut anytime we have

any big concern out of the gate. Yeah, so you saw it. And then did you have to work on the gut to get

antibodies down? Or what have you seen move the needle? I mean,

I know clinically we've seen a lot of stuff, but the personal cases are always the most

interesting because you're working on yourself. Yeah. So when we talk about like molecular mimicry

and or intestinal permeability, we make sure the foods are not causing our guts to be more

permeable. So the more inflammatory foods like gluten or maybe conventional dairy or any of your flowers or things that are going to contain glyphos, say anything non-organic, anything non-organic or high-fructose corn syrup, that's going to increase the gut permeability. The more permeable, the gut is the centurion guards, right? These are called the Toll-like receptor sites. They sit and they're constantly sensing. They sit by the interracites and they're

constantly sensing viruses and bacteria and microbial issues and inflammation. And they're allowing

those tight junctions to zip and unzip via the zonulin protein, right? Zonuline goes up.

...