The following Mark's Daily Apple article was written by Marksissons and is narrated by

Brock Armstrong. Is constant ketosis necessary or even desirable? Every day I get links to interesting papers.

It's hard not to when thousands of new studies are published every day,

and thousands of readers deliver the best ones to my inbox.

And while I enjoy thumbing through the links, simply for curiosity's sake,

they can also seed new ideas that

lead to research rabbit holes and full-fledged posts.

It's probably the favorite part of my day, research and synthesis and the gestation of future

blogs.

The hard part is collecting, collating, and then transcribing the ideas that are swirling

around inside my brain into readable prose, and hopefully getting an article out of it

that I can share it with you.

Last Sunday, I briefly mentioned a paper concerning a ketone metabolite known as beta-hydroxybutyrate, or BHB,

and its ability to block the activity of a set of inflammatory genes.

This particular set of genes, known as NLRP3 inflammation,

have been linked to Alzheimer's disease, atherosclerosis, metabolic syndrome, and age-related macular

degeneration. In other words, it's in our best interest to avoid its chronic, pathogenic

activation, and it looks like going into ketosis can probably help in that respect.

One thing led to another, and this paper got me thinking.

Once we go into ketosis, how long should we stay?

If some is good, is more better?

Is there a point where the benefits slow and the downsides accrue?

...