Is alcohol doing more damage in midlife than you realise? – with Prof David Nutt
Age Better with Liz Earle
Liz Earle
4.6 • 1.5K Ratings
🗓️ 27 March 2026
⏱️ 60 minutes
🧾️ Download transcript
Summary
Most of us know alcohol isn’t ideal for our health. But the specific ways it affects the brain, gut, hormones and our sleep, and why those effects become more pronounced as we age, are less well understood.
Leading psychiatrist and neuropsychopharmacologist Prof David Nutt joins Liz to explain exactly what happens in the body from the very first sip, why women become significantly more vulnerable in midlife, and what the science says about how to drink with healthy ageing in mind.
In this episode:
· Why alcohol affects women’s bodies differently – and more so in midlife
· What’s actually causing your hangover (it’s not just dehydration)
· How alcohol damages the gut and suppresses your immune system
· When even one drink disrupts deep, restorative sleep
· The brain chemical that makes us want to drink – and how to get it in other ways
· What drives addiction and why so many people use alcohol to manage stress, anxiety and trauma
· What cutting back for just one month can do for key health markers
· The growing world of functional alcohol alternatives
Links mentioned:
· Liz’s previous podcast with Prof David Nutt
More from David
Get in touch with a question for Liz:
- Email: podcast@lizearlewellbeing.com
- WhatsApp: 07518 471 846
More from Liz:
- Preorder Liz’s new book, How to Age
- A Better Second Half
- Follow Liz on Instagram
- Follow Liz Earle Wellbeing on Instagram
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Transcript
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| 0:00.0 | women become much more vulnerable to the negative effects of alcohol during the |
| 0:03.9 | medicals. But by and large, two things happen when you drink alcohol. The first is you |
| 0:08.5 | depress the activity of the good bugs. And you also inflame in the same way as you inflame |
| 0:14.7 | the liver and the brain, you inflame the wall of the gut. And of course, drinking strongly |
| 0:19.4 | associated with inflammation in the stomach. |
| 0:21.9 | You then start to interfere with the intrinsic immune system. So alcohol dampens down |
| 0:27.9 | immune function, which is why people who drink a lot are much more vulnerable to infections. |
| 0:33.3 | So do you want to have a relaxing drink and feel more confident with friends without the hangover and concerning health impacts? |
| 0:41.2 | Well, Professor David Nutt can show you how. |
| 0:44.1 | Hello and welcome to Age Better with me, Liz Earle. |
| 0:47.2 | My mission, as you know, is to change the conversation around ageing because you know we can decide just how well to thrive in later life in so many ways |
| 0:56.6 | ageing well is a journey and i want you to discover just how good it can feel to age better than you |
| 1:03.3 | ever thought possible and of course no conversation i think would be complete without a really |
| 1:09.1 | deep dive into alcohol especially especially as we age, |
| 1:12.5 | you know, for midlife women and older, it seems to affect us even more. And yet the pressures |
| 1:17.3 | for social drinking are never greater. Well, leading psychiatrist and neuro-psychopharmacologist, |
| 1:24.9 | Professor David Nutt, is a leader in the study of the brain, drugs and |
| 1:29.9 | conditions like addiction, anxiety and sleep. And he's going to explain exactly what alcohol does |
| 1:36.1 | to our bodies and our minds in the minutes and years after having a drink. |
| 1:47.3 | Well, welcome back, David. |
| 1:49.3 | I think this is the second time that we've spoken. |
| 1:53.7 | You were an early guest of mine, weren't you, on one of my formative first podcasts. |
... |
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