4.2 • 639 Ratings
🗓️ 8 January 2019
⏱️ 3 minutes
🧾️ Download transcript
Click on a timestamp to play from that location
0:00.0 | Understanding the human body is a team effort. That's where the Yachtel group comes in. |
0:05.8 | Researchers at Yachtolt have been delving into the secrets of probiotics for 90 years. |
0:11.0 | Yacold also partners with nature portfolio to advance gut microbiome science through the global grants for gut health, an investigator-led research program. |
0:19.6 | To learn more about Yachtolt, visit yawcult.co. |
0:22.7 | .jp. That's Y-A-K-U-L-T.C-O.J-P. When it comes to a guide for your gut, count on Yacolt. |
0:33.6 | This is Scientific American's 60-second science. I'm Christopher in Taliatta. |
0:39.0 | Your genome is sort of like a library, with each gene an instruction manual for making proteins. |
0:44.9 | The bad news is you can't return a book and take out a new edition. |
0:48.7 | But the technique of gene therapy allows you to revise your copy of the book, so to speak, |
0:53.7 | giving you the ability, potentially, |
0:55.6 | to make new and different proteins. Now scientists have experimented with a new way to make text |
1:01.0 | revisions by inhaling the changes. They tested the concept by having mice breathe-in genetic material |
1:07.4 | called Messenger RNA, or MRNA. For the test, the MRNA included instructions |
1:13.2 | to manufacture luciferase, the stuff that lights up in fireflies. The researchers packaged |
1:18.8 | the MRNA with a degradable polymer to trick the mice's lung cells into accepting the package. |
1:24.4 | And once the cells gobbled it up, they began to glow, proving that inhaling |
1:28.7 | RNA is an effective way to kickstart the production of new and novel proteins, like the firefly enzyme. |
1:35.6 | The scientists also repeated the experiment in mice whose cells had been genetically engineered |
1:40.1 | to turn permanently red if they received a copy of MRNA, making it possible to count the |
1:46.3 | proportion of cells affected by a dose. |
1:49.2 | The proof of concept is in the journal Advanced Materials. |
1:52.7 | Of course, the point of all this isn't to make mice glow. |
... |
Please login to see the full transcript.
Disclaimer: The podcast and artwork embedded on this page are from Scientific American, and are the property of its owner and not affiliated with or endorsed by Tapesearch.
Generated transcripts are the property of Scientific American and are distributed freely under the Fair Use doctrine. Transcripts generated by Tapesearch are not guaranteed to be accurate.
Copyright © Tapesearch 2025.