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Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Ibuprofen Pharmacology

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5716 Ratings

🗓️ 28 January 2021

⏱️ 15 minutes

🧾️ Download transcript

Summary

On this episode of the Real Life Pharmacology Podcast, I discuss ibuprofen pharmacology.



Ibuprofen can raise the concentrations of lithium and increase the risk for toxicity.



Compared to most other NSAIDs, ibuprofen has a relatively short half-life. This explains why it needs to be dosed more frequently than other agents.



Ibuprofen can contribute to renal insufficiency, GI bleed risk, and CHF exacerbations.

Transcript

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0:00.0

Hey all, welcome back to the Real Life Pharmacology podcast. I'm your host, pharmacist Eric Christensen.

0:07.1

Probably easiest to track me down if you got comments, suggestions on LinkedIn. I'd be Eric

0:13.0

Christensen, FarmD, BcGP, Bcps. I'll also reach out at MedEducation 101 at gmail.com.

0:22.6

And of course, as always, go to real-life pharmacology.com.

0:25.7

Check out our free 31-page PDF.

0:28.9

I simply get it for subscribing to the podcast.

0:31.6

We update you when new episodes are available, as well as some of the new content, new books, things of that

0:40.2

nature as well as some special discounts from time to time too. So definitely go check that out.

0:46.4

Again, real-life pharmacology.com. Snag your free 31 page PDF.

0:51.6

All right. So ibuprofen is the drug of the day today. I have previously covered insides

0:58.3

in the past, but I wanted to dig into more specifics on this medication. So first off,

1:05.8

brand names that you're going to see used in clinical practice, Advil and Motrin.

1:11.1

Those are by far the most common.

1:13.6

And you'll hear patients talk about these as well.

1:15.8

So definitely a nice one to know the brand name there.

1:20.2

Classification, it is an insid, as I mentioned.

1:22.6

So it's got analgesic properties, antipyretics, so it can manage fevers.

1:28.3

And that's really mostly what it's going to be used for.

1:31.7

So pain relief, you know, fever relief, as well as associated with that pain,

1:36.6

obviously anti-inflammatory or inflammation relief there as well.

1:42.1

Mechanistically, how it does some of those things. So ibuprofen is technically

1:48.0

classified as a non-selective insid, which means it inhibits Cox 1 and Cox 2. Ultimately, that

...

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