Hey all, welcome back to the Real Life Pharmacology podcast. I'm your host, pharmacist, Derek Christensen.

Thank you so much for listening today. As always, go check out Real Life Pharmacology.com.

If you haven't already, snag your free 31-page PDF on the top 200 drugs. Great little study guide.

If you're looking to brush up on your skills,

remember a few things, or if you're preparing for board exams, pharmacology finals, things like that,

just great refreshers of things that commonly come up in practice and things that you may see

come up on exams as well. So the drug of the day today is aeropipyprosol.

A brand name of this medication is Abilify. This medication is classified as an antipsychotic.

Now any drug typically that's classified as an antipsychotic is going to have activity on dopamine receptors.

Now, Abilify, rarapriazole is slightly different in that it isn't quite as strong of a dopamine blocking agent at that D2 receptor as some of the other classically known antipsychotics, such as, you know, haloperidol or respiradone.

It's more of a partial agonist, so that mild stimulation, but it also blocks the dopamine 2 receptor

from being basically fully agonized or fully stimulated. And so if you remember from, you know,

pathophysiology and things like that.

Excessive dopamine is typically thought to be a significant component of causing symptoms of schizophrenia,

hallucinations, delusions, things of that nature.

So by, you know, blocking, reducing the activity of dopamine, it makes sense that it could potentially help those type of diagnoses.

In addition to that partial agonist at the D2 receptor, it's got some action on serotonin reupttake potentially, milder antihistamine type effect,

also milder alpha blocking effect compared to some other antipsychotics.

And we'll kind of touch on that a little bit in the adverse effect profile,

where it maybe differs from some of the other antipsychotics.

So uses. In clinical practice, I've certainly seen it for things like schizophrenia, bipolar disorder,

where we've got those hallucinations, delusions, a lot of those positive symptoms associated with schizophrenia, for example.

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