All right, so welcome back to the Internet Book of Critical Care podcast.

I'm here with Adam Thomas and we're going to talk about vasopressers.

A core of our job, Josh.

If we don't understand how to defend the map and what tools we have in our toolbox for this,

we're not really doing our job well.

So today we'll talk about core agents, I know dilators, pure vasopressers, and the I know pressers. We'll go over a potpourri

of awesome things and we'll even throw a little oral cheating with midadrine and some

methylene blue in there. So let's move straight into it. We got some alpha, we got some beta, we got

some crazy pathways. Talk to

me about the overview of our vasoactive agents. There's a table here and there's a chart, and I think

the chart's kind of fun to look at because it basically compares the amounts of ionotropy

and vasoconstriction between the different agents. And it points out in some ways that phenolephrine,

vasopressin, and midicrin are very, very similar.

And norepidephrin is also predominantly a vasoconstrictor as well, which I just find interesting

because oftentimes folks seem to worship nor epinephrine and demonize phenopherin, but their

physiologic effects are pretty similar. So take a look. I think clinically memorizing,

is it three plus for beta versus 2 plus is not really that helpful.

But the big categories here are I know dilettators like your dobutamine, your mil renone,

and your isopraternal, your peer pressors like phasopressin, phenolephrine, or ephedrine,

depending what continent you're on.

I know pressers like norephenephrine, epinephrine, dopamine at variable doses, and we could say

that's real or not.

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