All right, so welcome back to the Internet Book of Critical Care podcast.

I'm here with Adam Thomas and we're going to talk about anaphylaxis.

You can't resuscitate if you don't know how to cover this right away because you don't

have a lot of time when the patient's crashing in front of you.

So today this is going to be a relatively quick podcast because there's not a huge topic to cover here,

but we need to know the basics very, very well.

So the kitchen sink and then all the sequelae that you can have.

Let's get straight into it, Josh.

Clinical findings and clinical definition of anaphylaxis, because I think a lot of the time

is people aren't thinking that this is anaphylaxis.

They don't appropriately address it.

And of course, epinephrine not giving it if you don't think it's anaphylaxis increases mortality.

So let's cover it to be sure. Anaphylaxis can involve multiple different organs. And this can be

tricky because it's not going to always involve the same exact pattern of organs and the same

constellation. But the key ones are probably number one,

at least in my mind, would be the skin and the mucous membranes. This is going to be seen in about

80 or 90% of patients. You can have flushing, urticaria, itchiness, antioedema, conjunctivitis, stuff

like that. Then other major organ systems involved cardiovascular. Certainly we can have cardiovascular

collapse, hypotension, shock, syncope, death, pulmonary involvement. This can be

the upper airway, strider, and also the lower airway with bronchospasm. Patients can have

dysmia and cough. And finally, GI manifestations, nausea, vomiting, abdominal discomfort, diarrhea.

I'm going to skip forward to the definition and then we're going to come back to crinicity

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