Hello and welcome to the zero to finals podcast. My name is Tom and in this episode I'm going to be

talking to you about hypothyroidism. And if you want to follow along with written notes on this topic,

you can follow along at zero tofinals.com slash hypothyroidism or in the endocrinology section of the zero to finals medicine book.

So let's get straight into it.

Hypothiridism is the term used to describe inadequate output of thyroid hormones by the thyroid gland.

There's a number of causes that we're going to go through. Hashimoto's

thyroiditis is the most common cause of hypothyroidism in the developed world. It's caused by

autoimmune inflammation of the thyroid gland and it's associated with antithyroid pero

antibodies and antithyroglobulin antibodies.

Initially it causes a goiter after which there's atrophy of the thyroid gland.

Iodine deficiency is the most common cause of hypothyroidism in the developing world.

Iodine is added to foods such as table salt in order to prevent iodine deficiency in the developed world. Iodine is added to foods such as table salt in order to prevent iodine

deficiency in the developed world. Hypothyroidism can also be caused by treatment for hypothyroidism.

And all of the treatments for hypothyroidism have the potential to cause hypothyroidism, and this

includes carbamazole, propathyroidysil, radioactive iodine, and therod hypothyroidism, and this includes carbamazole, propathyoeuracil,

radioactive iodine, and thyroid surgery.

There are medications that can cause hypothyroidism.

Lithium inhibits the production of thyroid hormones in the thyroid gland,

and can cause a goiter and hypothyroidism.

Amiodarone interferes with thyroid hormone production and metabolism, usually causing hypothyroidism but it can also cause thyrotoxicosis. There can be

central causes which cause a secondary hypothyroidism and this is where the pituitary gland is failing to produce enough T-S-H and

this is often associated with the lack of other pituitary hormones such as ACTH and

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