meta_pixel
Tapesearch Logo
Log in
The Proof with Simon Hill

Hunger, weight loss and obesity | Stephan Guyenet, PhD

The Proof with Simon Hill

Simon Hill

Nutrition, Education, Self-improvement, Health & Fitness

4.9 • 3.1K Ratings

🗓️ 15 May 2023

⏱️ 128 minutes

🧾️ Download transcript

Summary

Episode #260. Are you struggling to maintain a healthy weight and navigate the confusing world of diets and weight loss solutions? In this episode, join me as I dive into the science behind eating behaviours, obesity, and the challenges of losing weight with renowned researcher Dr Stephan Guyenet. Discover the different types of eating, the importance of controlling our food environment, and various evidence-based strategies for weight loss. With practical advice and insights from Dr Guyenet, you'll gain a better understanding of the complexities of weight management and how to make informed choices for your health. Don't miss this eye-opening conversation about the widespread issue of obesity and our brain's role in eating behaviours. Specifically, we discuss: Intro (00:00) From neurodegenerative disease to obesity neuroscience (01:36) The holiday weight gain (10:38) The problem with excess fat (14:37) 'Personal fat threshold' and diabetes (26:06) Main drivers of type 2 diabetes (31:26) The role of the hypothalamus in weight gain (38:55) Homeostatic vs. non-homeostatic eating (47:29) Genetics and the obesity epidemic (56:50) Models of obesity: carbohydrate -insulin vs. energy balance (1:00:21) The brain and obesity (1:10:34) The protein-leverage hypothesis (1:19:39) Carbohydrates, fat, and the Mediterranean diet (1:24:08) The weight loss puzzle: low carb vs. low fat diet (1:30:10) Foods that promote satiety on fewer calories (1:38:25) GLP-1 agonists (1:43:08) Is weight loss largely dependent on exercise? (1:55:06) Physical activity vs sedentary lifestyle (1:58:40) Mental health and sleep (2:00:28) Expert advice on how to stop overeating (2:05:11) Outro (2:05:59) To connect with Dr Stephan Guyenet, you can find him on Twitter or visit his website, https://www.stephanguyenet.com/. You can also purchase Dr Guyenet’s widely acclaimed book, The Hungry Brain, to learn more about why we overeat and how to overcome this issue. Make sure to also check out Red Pen Reviews, where you can access free expert reviews on nutrition books. Discover more insights and supporting resources in the full show notes. Enjoy, friends. Simon Want to support the show? The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family. Simon Hill, MSc, BSc (Hons) Creator of theproof.com and host of The Proof with Simon Hill Author of The Proof is in the Plants Watch the episodes on YouTube or listen on Apple/Spotify Connect with me on Instagram, Twitter, and Facebook Nourish your gut with my Plant-Based Ferments Guide Download my complimentary two-week meal plan and high protein Plant Performance recipe book

Transcript

Click on a timestamp to play from that location

0:00.0

Hey there, I've got a very quick message to share with you before we jump into the

0:07.0

episode.

0:08.0

Let's keep this under 30 seconds, shall we?

0:11.5

This episode is proudly brought to you by Amille.

0:13.7

Amille is a plant-based wellness company focused on formulating evidence-based supplements

0:18.2

to optimize our health.

0:20.0

I personally take Amille's essential aid multi-nutrient to how I start my day, which contains

0:25.0

eight essential nutrients in the right forms and dosages to perfectly complement a plant-rich

0:30.1

diet.

0:31.1

Amille offers no magic pills or hyperbolic claims, just good quality supplements that

0:36.3

we can trust.

0:37.3

To check out Amille and get 10% off your first order, visit theproof.com-forwardslashfriends.

0:42.6

I'll pop a link to that in the show notes.

0:48.8

There's been an enormous increase in obesity rates.

0:52.0

It's been kind of increasing gradually over a long period of time.

0:56.0

However, the pace accelerated sometime between the mid-1970s and mid-1980s.

1:02.8

And so at this point, in the United States, 43% of US adults have obesity.

1:10.1

And that doesn't include people who are overweight.

1:13.9

That is just people with obesity, body mass index, over 30.

1:21.8

Welcome to theproof podcast, a space for science-based conversation exploring the health

1:26.7

and longevity benefits that come with mastering nutrition, physical exercise, mindfulness,

1:32.8

recovery, sleep and alignment.

...

Please login to see the full transcript.

Disclaimer: The podcast and artwork embedded on this page are from Simon Hill, and are the property of its owner and not affiliated with or endorsed by Tapesearch.

Generated transcripts are the property of Simon Hill and are distributed freely under the Fair Use doctrine. Transcripts generated by Tapesearch are not guaranteed to be accurate.

Copyright © Tapesearch 2026.