HRT Isn’t Enough: Why You Still Need to Build Muscle | Solo

The Dr. Tyna Show

Dr. Tyna Moore

Alternative Health, Health & Fitness

4.9 • 1.7K Ratings

🗓️ 27 April 2026

⏱️ 50 minutes

🔗️ Recording | iTunes | RSS

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Summary

EP. 258: Get Strong with Me Inside my NEW Strength Vault: https://www.drtyna.com/offers/G33fSdvSIn this episode, I’m breaking down one of the most frustrating conversations happening in women’s health right now, the claim that estrogen and hormone replacement therapy don’t support muscle mass. The reality is more nuanced. I walk through what the current research actually shows, where it’s strong, where it’s inconsistent, and how estrogen interacts with skeletal muscle at a physiological level. We’re talking about estrogen receptors in muscle, mitochondrial function, anabolic signaling, insulin resistance, and why outcomes around muscle are often context-dependent. I also share what I’ve observed clinically after decades of working in a musculoskeletal setting, and how factors like metabolic health, training status, and overall tissue quality may influence how hormone therapy plays out in the real world. This episode isn’t about claiming HRT builds muscle. It’s about understanding how estrogen affects muscle biology, and why strength training remains a non-negotiable piece of the equation. Topics Discussed: → Estrogen and muscle growth → HRT and menopause fitness → Strength training for women over 40 → Insulin resistance and muscle health → Hormones and metabolic health Sponsored By: → Ogee | Thanks to today’s sponsor, Ogee: A higher standard for beauty. Go to https://ogee.com/DRTYNA and use code DRTYNA to get 15% off certified organic makeup that performs like luxury. → EnergyBits | If you want a simpler, smarter way to support your body… this is it. Head to https://ENERGYbits.com and use code DTS for 20% off your order. → Puori | Go to https://puori.com/DRTYNA and use the code DRTYNA at checkout to get 32% off your first Protein subscription order and get a free shaker worth $25. → BIOptimizers | For an exclusive offer, go to https://bioptimizers.com/drtyna and use code DRTYNA for 15% off + a FREE MassZymes bottle. Limited time, while supplies last. → Timeline | Timeline’s clinically proven formula is now available at a new, lower price. Mitopure now starts at $79, when you go to https://timeline.com/drtyna → Sundays | Make the switch to Sundays. Go right now to https://sundaysfordogs.com/DRTYNA50 and get 50% off your first order. Or, you can use code DRTYNA50 at checkout. On This Episode We Cover: → 00:00:00 - Introduction → 00:01:24 - HRT Misinformation → 00:03:20 - Rejentivite Injection Therapy + HRT → 00:06:48 - You Must Strength Train → 00:07:57 - Scientific Overview → 00:11:19 - Building Skeletal Muscle → 00:14:47 - Estrogen’s Impact On Muscle → 00:19:44 - HRT + Metabolic Health → 00:24:05 - Estrogen + Muscle Pathways → 00:26:57 - Why Muscle Suddenly Disappears → 00:29:52 - Insulin Resistance → 00:36:36 - Quality Of Life Improvement → 00:40:25 - Post Menopausal Studies → 00:40:25 - Improving HRT → 00:44:26 - HRT + Muscle Environment Show Links: → Transdermal Estrogen Therapy Improves Gains in Skeletal Muscle Mass After 12 Weeks of Resistance Training in Early Postmenopausal Women → The role of estrogen in female skeletal muscle aging: A systematic review → Mechanisms of Estrogen Influence on Skeletal Muscle: Mass, Regeneration, and Mitochondrial Function → Muscle in Endocrinology: From Skeletal Muscle Hormone Regulation to Myokine Secretion and Its Implications in Endocrine–Metabolic Diseases → New Meta-Analysis Shows That Hormone Therapy Can Significantly Reduce Insulin Resistance Further Listening: → The TRUTH Behind Menopausal Pain & What You Can Do About It | Ep 256 Disclaimer: Information provided in this podcast is for informational purposes only. This information is NOT intended as a substitute for the advice provided by your physician or other healthcare professional, or any information contained on or in any product. Do not use the information provided in this podcast for diagnosing or treating a health problem or disease, or prescribing medication or other treatment. Always speak with your physician or other healthcare professional before taking any medication or nutritional, herbal or other supplement, or using any treatment for a health problem. Information provided in this blog/podcast and the use of any products or services related to this podcast by you does not create a doctor-patient relationship between you and Dr. Tyna Moore. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent ANY disease.

Transcript

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0:00.0	You are tuned into the Dr. Tina show with Dr. Tina Moore. For more, visit Dr. Tina.com.
0:06.9	On this episode of the Dr. Tina show, I'm going to be talking to you about estrogen, hormone
0:12.2	replacement therapy, and muscle. I'm going to tell you everything you need to know from the latest
0:17.2	data that I pulled up. The reason I'm doing this episode is because for some reason out there,
0:23.3	there is a group of PhD scientists, some young women, some older men,
0:29.1	who really want to claim that estrogen replacement therapy and hormone replacement therapy
0:34.6	does not help muscle mass.
0:36.7	And that's just plain wrong.
0:38.0	So we're going to get into it.
0:39.4	Okay, with all due respect, the folks I'm talking about are brilliant people.
0:43.3	All right?
0:44.1	They're really hung up on the data and they're really doubling down on this concept
0:50.6	that estrogen in particular does not help muscle mass. Why? I do not know. But
0:57.6	because they do not have a direct causative study, they're claiming this. And that's where I think
1:04.8	everybody's missing the mark. We don't need a direct causative study to look at physiology and backtrack and decide how this piece is together ultimately to influence positive impacts on muscle mass.
1:20.9	Estrogen does help muscle mass, and I'm going to tell you why.
1:24.6	So first off, this post came in, I saw it, I don't know, a couple days ago,
1:30.8	and it basically was saying that menopause hormone therapy isn't a panacea. And they listed off
1:39.4	several symptoms that, you know, it may help with, but it helps with symptoms and not specifically the condition
1:49.3	itself. And again, we don't have a direct causative study showing that you give somebody
1:55.9	estrogen and muscle mass is significantly improved. But we have plenty of studies that are very recent that I was pretty, you know, easy,
2:06.4	they were pretty easy to dig up, that show estrogen does indeed impact muscle mass.
	...

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