How Urolithin A Drives Mitochondrial Renewal and Slows Immune Aging
Dr. Joseph Mercola - Take Control of Your Health
Briana Mercola
4.6 • 1.5K Ratings
🗓️ 15 January 2026
⏱️ 8 minutes
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Summary
- As you age, your thymus produces fewer newly formed cells responsible for responding to unfamiliar pathogens, reducing your immune system's adaptability. This shift, combined with persistent inflammation, defines the core features of immune aging
- Urolithin A, a postbiotic compound, stimulates mitochondrial renewal in aging immune cells. A recent study shows it can increase naïve-like T cells and strengthen immune surveillance in just four weeks of supplementation
- Clinical findings show that urolithin A boosts mitochondrial renewal pathways, increases markers linked to mitochondrial biogenesis, and improves immune cell metabolism
- Beyond immune health, studies reveal that urolithin A influences cancer pathways, enhances muscle strength and endurance, improves fatty liver markers, and reshapes metabolic signaling involved in obesity and insulin resistance
- Beyond using urolithin A, you can also support your mitochondria by lowering linoleic acid intake, eating the right carbohydrates, limiting environmental toxins, and supporting NAD⁺ production with niacinamide
Transcript
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| 0:00.0 | What if renewing your mitochondria could make your immune system act younger within a month? |
| 0:05.0 | Welcome to Dr. Mercola's cellular wisdom. Stay informed with quick, easy-to-listen summaries of our latest articles, |
| 0:12.0 | perfect for when you're on the go. No reading required. Subscribe for free at Mercola.com for the latest health insights. |
| 0:18.0 | Hello, and welcome to Dr. Mercola's cellular wisdom. |
| 0:22.7 | I'm Ethan Foster, and today we're examining how Eurolithin A may help you counterimmune aging |
| 0:28.1 | by supporting mitochondrial renewal. |
| 0:30.9 | We'll look at what changes with age, what a recent clinical trial found, |
| 0:34.8 | and the practical steps you can take to strengthen cellular energy. |
| 0:38.6 | I'm Alara Sky. You'll hear how naive T cells, natural killer cells, and mitochondrial biogenesis |
| 0:45.9 | markers shifted after short-term supplementation. Why only some people naturally produce |
| 0:51.2 | urolithin A from foods, and how strategies like lowering |
| 0:54.7 | linoleic acid and supporting NAD plus fit into the bigger picture. |
| 1:00.0 | As you age, your thymus produces fewer newly formed T cells, which limits fresh responses |
| 1:05.2 | to unfamiliar threats. At the same time, memory T cells accumulate, making your immunity less adaptable. |
| 1:12.6 | Persistent low-grade inflammation, often called inflamaging, rises in the background. |
| 1:18.0 | Together, those shifts explain slower first-time responses and reduce flexibility in later decades. |
| 1:24.4 | A randomized study published in nature aging followed healthy adults, 45 to 70 years old, |
| 1:30.5 | who took either 1,000 milligrams of urolithin A daily or placebo for four weeks. |
| 1:36.7 | Researchers analyzed blood at the start and end to see if mitochondrial support could reshape |
| 1:41.3 | immune cell composition and function over that short window. |
| 1:45.0 | Participants who received Eurolithin A showed an increase in naive-like CD8 T-cells and fewer signs of exhaustion. |
| 1:53.0 | These T-cells also demonstrated about a 15% improvement in using fatty acids for energy, |
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