How to Diet Without Losing Muscle with Dr. Eric Trexler
RP Strength Podcast
Dr. Mike Israetel, Nick Shaw
4.7 • 582 Ratings
🗓️ 12 January 2026
⏱️ 79 minutes
🧾️ Download transcript
Summary
Want to get even more jacked? Grab the RP Hypertrophy App for your training, and maximize your gym efforts with the RP Diet Coach App to nail your nutrition.
00:00 - Christmas magic ✨
04:10 - Dr. Mike's distain for modern Batman
06:05 - Bodybuilders ≠ Hollywood
12:20 - Muscle loss isn't one-size-fits-all
24:30 - Does diet duration effect muscle loss?
28:30 - Do men lose more muscle when dieting?
34:40 - Are people losing excess muscle on Ozempic?
40:40 - Organ size shifts when gaining and losing fat
44:00 - Factors that make muscle loss worse in a deficit
50:15 - Setting realistic body fat targets
1:00:00 - Best rate of loss / Protein intake / Cardio for muscle retention
1:06:00 - Objections to modern weight loss drugs
1:12:45 - Carb/macro intake for muscle retention
Transcript
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| 0:00.0 | Welcome, everyone to the R.B. Stringed podcast. I'm Nick Shaw, joined by the one and only Dr. Mike. What's up, man? |
| 0:11.3 | Mr. Nick Shaw, how are you? It's good to be here. Thank you for referring to me by that name. |
| 0:15.9 | I only like to go by that. Everyone knows that. And we have a third guest, quite frankly, enjoy Ambien on the podcast, way more than Dr. |
| 0:24.8 | Mike, but Dr. Eric Trexler from right up the road from me at Duke University. |
| 0:30.8 | Eric, how are you? |
| 0:32.1 | I'm doing great. |
| 0:32.9 | How are you? |
| 0:34.4 | Quite lovely. |
| 0:35.4 | How was your guys' a holiday break Christmas Mike Mike |
| 0:42.5 | you guys are both Jewish so we feel weird asked them about Christmas but perhaps you're |
| 0:47.8 | Jewish well it's complicated grew up Catholic then became kind of a non-denominational Christian, then married a Jewish woman. |
| 0:57.0 | So when it comes to the holidays, I just go for the cycle. I try to get as many as I can. |
| 1:03.0 | Yeah, that's such a great idea. I am also complicated. I grew up in Russia. There, you didn't talk about being Jewish, so there was no Hanukkah. |
| 1:18.6 | And the communists made much of Christianity illegal, but they had to conserve some of the practices. |
| 1:26.1 | So what they did was they reconstructed most of the |
| 1:29.4 | practices of Christmas and put it on New Year's. And so it was a secular holiday. So Santa Claus, |
| 1:36.5 | who was renamed Grandfather Frost, was somebody who would show up and give you gifts and you'd have a |
| 1:43.3 | tree, but it was on New |
| 1:44.5 | years. So New Year's Eve, he ostensibly climbed through chimneys, even though most people |
| 1:49.8 | lived in giant apartment buildings and would deliver gifts. And then so I actually grew up |
| 1:55.7 | celebrating basically Christmas for the first seven years of my life. So to me, Christmas is like an irreplaceable magical time. |
| 2:03.3 | I am a person who gladly will listen to Christmas music on October 31st and on. |
... |
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