If you know anything about Samantha B, it's that she's not afraid to joke about pretty much anything.

At this point, you might be having a negative opinion, which brings me to my next lesson.

I don't give a shit about your personal opinions.

The Emmy-winning comedian and writer spent seven years as the host of her own show, full-frontal with Samantha B.

Before that, she was a correspondent for The Daily Show with John Stewart, the only female correspondent at the time.

But now, Samantha's taking her jokes to a place she's never gone before.

It is so satisfying for me to talk about all the bullshit that goes along with menopause in a way

that is totally raw and dumb.

It's cleansing.

In a new one-woman show, Samantha's bearing all and talking about her journey through menopause.

Something that, as she points out, half the world's population will experience, and yet many of us don't want to talk about it.

Samantha says she even got pushed back on the concept of a show about menopause.

Definitely, definitely have talked about it as a show and had people say the words, can you just take the word

menopause out of it?

I just turned 40.

So as the internet keeps reminding me, menopause could be right around the corner.

And I'm already learning firsthand just how right Samantha is.

Menopause is still something we don't talk about enough, whether it's in medicine,

as a culture, or just among friends and family. So this week, Dr. Sanjay Gupta is passing me

the mic, and Samantha and I are confronting menopause head-on. I'm CNN medical correspondent Meg Terrell,

and this is Chasing Life.

Samantha B. Thank you so much for doing this. Are you kidding? It is a pleasure. I love talking about menopause. How much of your time is taken up talking about menopause these days?

...