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The a16z Show

How Marc Andreessen Actually Uses AI

The a16z Show

a16z

Science, Innovation, Business, Entrepreneurship, Culture, Disruption, Software Eating The World, Technology

4.41.1K Ratings

🗓️ 25 November 2025

⏱️ 34 minutes

🧾️ Download transcript

Summary

Half a billion people can access the world’s best AI on their phone. So why are most using it to write emails while only some are using it to build empires? In this conversation with Mark Halperin from Next Up, Marc Andreessen reveals why small bakeries are beating Fortune 500 companies at AI adoption, how to turn ChatGPT into your personal board of directors, and why Silicon Valley just reversed five years of geographic dispersion overnight. He also shares the questions that unlock AI's real power—including one of his favorite prompts: "What questions should I be asking?"

Transcript

Click on a timestamp to play from that location

0:00.0

This is already probably the most democratic, you know, small D technology of all time in the sense of the very best I are in the world is fully available on the apps that anybody can download. This is just a completely different kind of computer that has these characteristics that are frankly more like a person, which is it's right most of the time. It occasionally gets things wrong. When it gets things wrong, it's able to self-outique. And you have to kind of work with it the way that you work with a person.

0:40.5

You want to take advantage of the fact that it's creative, and then you want to be tolerant of the fact that it's not always correct. AI basically has snapped everything right back into the 20-month-square radius around where I sit to just an incredible degree. So I would say like almost 100% of the actually interesting AI companies in the West are happening.

0:39.7

It's sort of ground zero right here in Silicon Valley.

0:43.1

There's a bakery owner somewhere using the same AI as Google CEO,

0:47.0

and according to Mark Andreessen, the bakery owner is winning.

0:50.1

The man who invented the modern web browser and built multi-billion dollar companies

0:53.9

just revealed something remarkable.

0:56.0

AI is spreading backwards to society.

0:58.3

Individuals first, small businesses second, Fortune 500 companies third, government lasts.

1:03.8

The exact opposite of how computers evolve from mainframes to smartphones.

1:07.9

Mark says half a billion people already have the world's most sophisticated AI

1:11.0

on their phones, so the question is, why are most using it to write emails while only some

1:15.6

are using it to build empires? Today, we're sharing a conversation Mark Andreessen had with

1:20.3

Mark Halperin on his show Next Up. They talk about a specific prompts that transform AI into a world-class

1:26.0

advisor, why Silicon Valley just snapped back

1:28.6

into a 20-mile radius after five years of dispersion, and the uncomfortable truth about America's

1:33.9

AI race with China. We hope you enjoy.

1:40.5

All right, next up, Mark Andriesen, innovator, creator, and damn successful businessman.

1:46.9

Early on, he invented the Mosaic Internet browser, co-founded Netscape.

1:50.5

And since then, he has been the animating force and investor behind a lot of very successful companies, including some at the multiple billion dollar level,

2:02.2

co-founded his firm, Andreessen Horowitz, a general partner there, and they do a lot of

2:09.3

stuff about a lot, a lot, a lot of stuff, and he knows a lot about a lot. Mark, welcome.

...

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