How Dogs Are Going to Make You Live Longer: Rapamycin & Longevity – Matt Kaeberlein : 1145
The Human Upgrade with Dave Asprey
Dave Asprey
4.6 • 7.3K Ratings
🗓️ 19 March 2024
⏱️ 86 minutes
🧾️ Download transcript
Summary
How can we make our furry best friends live longer, healthier lives?
A true pioneer in this field, Dr. Matt Kaeberlein, is here to unpack this important subject while highlighting the crossover between human and canine longevity. You read that right; this episode isn't just for dog lovers—it's a deep dive into longevity for humans, too.
Dr. Matt Kaeberlein, who's the CEO of Optispan and a key figure in the Dog Aging Project, brings a wealth of knowledge from his distinguished career in aging and healthspan research. He's an Affiliate Professor at the University of Washington and a notable figure in gerontology, recognized by organizations like the American Association for the Advancement of Science and the Gerontological Society of America.
Matt's work is groundbreaking, demonstrated in over 250 scientific papers on aging, numerous prestigious awards, and he's even a Fellow of several aging associations. He's on a mission to unlock the secrets of aging, not just in humans, but in our four-legged companions as well.
We explore the accuracy of measuring age with telomeres versus epigenetics and get into the nitty-gritty of diet's impact on longevity for both dogs and humans, reminding us it's not just about living longer, but living well.
Matt explains the impressive trial results on rapamycin for reducing age-related inflammation, a breakthrough that's not just exciting for us but also for our pets. Finally, we touch on how AI is revolutionizing our approach to understanding and extending our healthspan.
For those who want to get more involved, check out dogagingproject.org. It's not every day you meet someone who's made such significant strides in understanding aging across species. So whether you're a pet parent or just passionate about extending your own health span, this episode is for you.
(00:01:31) Dogs Are the Bridge Between Lab Studies & Human Longevity
(00:11:09) Exploring the Impact of Diet on Longevity
(00:18:50) How Our Unique Biology Impacts Aging
(00:26:33) Exploring How Size & Diet Impact Health Across Species
(00:37:55) Fighting Age-Related Inflammation with Rapamycin
(00:56:40) AI Interventions for Longevity Testing
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Resources
Dave Asprey’s NEW Book ‘Smarter Not Harder’ is out now: https://daveasprey.com/books
Learn More: dogagingproject.org
Website: optispan.life
X: @mkaeberlein
Listen: The Optispan Podcast with Matt Kaeberlein
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Transcript
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| 0:00.0 | You're listening to the human upgrade with Dave Asprey. |
| 0:06.0 | Formerly Bulletproof Radio. Hi. Dave Asprey. Today we're going to talk about dogs, specifically how to hack your dog to live a lot longer. |
| 0:28.8 | Okay, maybe not quite, but maybe. Our guest is Matt Paperline who's working on exactly that |
| 0:37.0 | extending radically extending the lifespan of dogs and other pets as well but starting with dogs because dogs are better than |
| 0:45.4 | cats in case you were wondering. Now what you're going to hear here is a really fun |
| 0:50.6 | conversation that mixes human longevity because Matt is the CEO of Optuspan |
| 0:56.6 | where they're extending human life or at least health span as much as they can. |
| 1:00.3 | He's one of those guys who still says health span because he hasn't quite bought in on the fact that we are extending human life and that's the goal but I'm going to bring him over on this one |
| 1:08.2 | So you know that'll be fun. Oh, hey Matt, yeah, you didn't hear that right and? And then we're going to also talk about hacking your dog, |
| 1:15.6 | which is what I already mentioned. |
| 1:17.2 | And we're going to talk a lot about longevity |
| 1:20.2 | and your pets because there's such a commonality of humans and dogs so listen to the |
| 1:24.4 | episode you'll learn something about how to think about longevity for you and how |
| 1:28.8 | to translate it over to your pet. That's in town because it's south by southwest here in Austin, which means it's a madhouse. |
| 1:36.7 | How bad was the airport coming in? |
| 1:37.7 | You know, it was pretty crazy, but I made it, so that's all the counts. |
| 1:43.0 | My son is coming in he's flying by himself and he's probably never seen an airport at that level of chaos so I'm kind of looking forward to his eyes rolling back in his head as he just sees what... of here. You're also giving a talk on what you're working doing with pets. |
| 2:03.4 | Right. Yeah, so there's a panel discussion on, I think it's called something like, could |
| 2:08.8 | dogs be the key to unraveling human longevity or something like that. |
| 2:13.0 | But it's neat. |
| 2:14.0 | So you're doing the dog aging projects. |
| 2:17.0 | And dogs have this really nice space between, in longevity research that a lot of my books are based on it all starts with yeast and roundworms and then maybe goes to mice right right and then maybe we have some other data somewhere or another and then we start using it with humans using aging clocks. |
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