Heart Failure Medications – Loops, SGLT2s, and ARNI – Test Prep and Practice Pearls
Real Life Pharmacology - Pharmacology Education for Health Care Professionals
Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist
4.9 • 773 Ratings
🗓️ 16 April 2026
⏱️ 17 minutes
🧾️ Download transcript
Summary
If you’re managing patients with heart failure, you already know the medication landscape has evolved quickly over the past decade. From traditional volume management with furosemide to newer, guideline-driven therapies like sacubitril/valsartan and empagliflozin, staying up to date is essential—but not always easy.
In this episode, we break down three cornerstone medication classes you’ll encounter every day in practice: loop diuretics, ARNI therapy, and SGLT2 inhibitors. We start with the fundamentals of loop diuretics—how they work, when to use them, and key monitoring parameters—before shifting into the mortality-reducing benefits of ARNI therapy. Finally, we explore the rapidly expanding role of SGLT2 inhibitors, which have transformed both heart failure and chronic kidney disease management.
Whether you’re a pharmacist, nurse, or student, this episode focuses on practical, real-world application. We highlight clinical pearls, common pitfalls, and monitoring strategies to help you feel more confident when optimizing therapy.
Tune in to sharpen your understanding of these essential therapies and walk away with actionable insights you can use right away in patient care.
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Transcript
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| 0:00.0 | Hey, all, welcome back to the real-life pharmacology podcast. |
| 0:03.4 | I'm your host pharmacist, Eric Christensen. |
| 0:05.4 | Thank you so much for listening today. |
| 0:07.6 | Today, I'm going to cover some heart failure medications. |
| 0:11.4 | Now, previously in the hypertension section and obviously on previous podcast, I've covered |
| 0:16.8 | beta blockers and industrial antagonists a little bit. |
| 0:20.3 | So go ahead and search the archives if you want a little bit deeper dive into those. |
| 0:25.6 | I'm going to focus on loop diuretics, Arnie, and SGLT2 inhibitors a little bit here. |
| 0:34.1 | So before I do that, be sure you go check out real life pharmacology.com. |
| 0:39.8 | We've got that free 31 page PDF. Absolutely no brainer for you to have. Great if you're out |
| 0:45.3 | in practice or you're taking board exams, pharmacology exams, good little review on some of the |
| 0:50.9 | most important things about the top 200 drugs. |
| 0:54.3 | So again, you can do that. |
| 0:55.9 | Simple an email, we'll get you access at real-life pharmacology.com. |
| 1:01.0 | All right, so heart failure medications. |
| 1:03.9 | So let's talk about loop diureetics first. |
| 1:08.2 | These medications are a mainstay in practice to essentially remove fluid. |
| 1:15.8 | Mechanistically, loop diuretics block sodium potassium chloride transport in the ascending loop of Henley. |
| 1:25.0 | So being in the loop of Henley in the kidney, that's where the name |
| 1:30.5 | Loop Diuretic comes from. And this yields, you know, the most powerful diuretic effect of |
| 1:38.1 | kind of any other standard medications that we utilize. It's typically considered much more |
| 1:43.4 | powerful than thiaside diuretics, |
... |
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