Genome Traces, Beavers and Wildfire, Halloween DIY, Volcanoes. Oct 22, 2021, Part 2
Science Friday
Science Friday and WNYC Studios
4.4 • 6.3K Ratings
🗓️ 22 October 2021
⏱️ 47 minutes
🔗️ Recording | iTunes | RSS
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| 0:00.0 | This is Science Friday. I'm Ira Flato. Later in the hour, it's the intersection of beavers and wildfires. |
| 0:08.0 | I know you're going to want to hear that. But first, the question you might have been thinking in the lead |
| 0:12.2 | up to Halloween, what does it mean to be human? Yeah, SciFrize Charles Berkwist is here. Hey, Charles. |
| 0:19.0 | Hey, Ira. So we're not talking vampires or |
| 0:22.0 | werewolves here. This is a study that took a close look at the human genome and tried to map out |
| 0:27.6 | where it intersects with the genomes of Neanderthals and Denisovans. So you mean other |
| 0:33.5 | lineages of humans that are not around today, but their genetic traces are. |
| 0:39.6 | Yeah, in fact, chances are that sprinkled through your genome, there are plenty of genes |
| 0:44.7 | that can be traced back to one or another of these groups. |
| 0:47.7 | Now, there must be parts of my genome that are unique to modern humans, no? |
| 0:54.0 | Some, not a lot. |
| 0:55.5 | I asked Ed Green, a professor of biomolecular engineering at UC Santa Cruz, if he could put a number |
| 1:01.8 | on it for us. |
| 1:03.7 | It is surprisingly small, the amount of our genome that you would never find in any Neanderthal, it is somewhere around a few |
| 1:15.4 | percent. And we did this two ways. One way, just saying all of the regions of the genome that are |
| 1:21.9 | uniquely human genetically, and then a smaller set of this is the regions of the genome that are uniquely human |
| 1:29.7 | and have what we call a fixed derived allele or some genetic novelty. So it didn't just get inherited |
| 1:38.9 | from humans in all humans today, but it actually has something new and different that's specific to |
| 1:45.2 | humans. And that fraction of the genome is less than 2%, very, very small amount of all of our DNA |
| 1:55.7 | is just coming from human ancestors and has something that could possibly be functionally relevant |
| 2:03.4 | because it's actually different than what was available in other archaic human groups. |
| 2:09.5 | How do you can get to that number? Walk me through that. |
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