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Into the Impossible With Brian Keating

From Pipe Bombs to Viagra: Nobel Prize Winner’s Secrets Revealed - Lou Ignarro - #521

Into the Impossible With Brian Keating

Brian Keating

Physics, Natural Sciences, Science

4.71.1K Ratings

🗓️ 6 October 2025

⏱️ 54 minutes

🧾️ Download transcript

Summary

Please join my mailing list here 👉 https://briankeating.com/list to win a meteorite 💥 Lou Ignarro went from building pipe bombs as a curious teen to winning the Nobel Prize for discovering how a gas—nitric oxide—regulates blood flow, fuels Viagra, and revolutionized cardiovascular medicine. In this explosive conversation, we trace how one molecule transformed sex, science, and the story of human health. Key Takeaways: 00:00 Intro  00:55 The molecule that saves and kills  04:00 The invention of the X-ray 05:44 Nitroglycerin: explosive or life-saving drug?  11:07 Fine-tuning and Lou’s religious beliefs  14:38 Judging a book by its cover  16:56 The importance of curiosity  20:00 Thoughts on the Nobel Prize 24:58 What does Viagra do and how does it work?  32:10 The importance of collaboration in scientific research  35:15 Achieving the breakthrough discovery  41:02 What happens if a woman takes viagra? 42:55 Other applications of nitric oxide  47:57 Lou’s heart-healthy diet  52:41 Outro Additional resources:  ➡️ Follow Lou Ignarro:  ✖️ Twitter: https://x.com/drignarro  📚 Dr. NO by Lou Ignarro: https://a.co/d/gSarIKX  ➡️ My new book: 📖 Into the Impossible Volume 2: Focus Like a Nobel Prize Winner: Lessons from Laureates to Concentrate Your Creativity and Ignite Your Career: https://a.co/d/hi50U9U  ➡️ Follow me on your fav platforms: ✖️ Twitter: https://twitter.com/DrBrianKeating  🔔 YouTube: https://www.youtube.com/DrBrianKeating?sub_confirmation=1  📝 Join my mailing list: https://briankeating.com/list  ✍️ Check out my blog: https://briankeating.com/cosmic-musings/  🎙️ Follow my podcast: https://briankeating.com/podcast  — Into the Impossible with Brian Keating is a podcast dedicated to all those who want to explore the universe within and beyond the known. Make sure to follow/subscribe so you never miss an episode! Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0

If you saw today's guest walking down the street, you might think retired grandfather, an industrial scientist, maybe a professor, but here's what you wouldn't guess.

0:10.7

He once made illegal pipe bombs in his basement and then discovered the molecule that powers certain other things that instead of taking down buildings, it's responsible for a certain type of

0:21.5

erection, shall we say. Biagra, he won the Nobel Prize and he rewrote medical textbooks. What's so

0:27.9

wonderful about this man, Lou Ignarro, he's written a book called Dr. No. It's about a magical

0:32.9

molecule that's in your blood right now and may be deficient in some of the listeners and we'll

0:39.2

talk about ways we can improve our life. So today's episode might save your life. It may make your

0:43.7

life better and it might improve your sex life. Welcome to the podcast, Dr. Liu Ignaro. How are you

0:51.3

today, sir? Fine. Great. Thanks, Brian. It's such a pleasure to be here.

0:55.2

It's really wonderful. I love this book. It's incredible. It really teaches you not exactly, you know, how to win a Nobel Prize, kind of the antidote to my book. You know, if my book and your book come together, it's like, Anteamatter, you know, losing the Nobel Prize. yours is winning the Nobel Prize,

1:09.0

but it tells you what it's like,

1:10.8

what it feels like,

1:12.3

to have the curiosity that, losing the Nobel Prize. Yours is winning the Nobel Prize. But it tells you what it's like,

1:17.3

what it feels like to have the curiosity that unintentionally took you all the way to Stockholm.

1:23.7

So I want to ask you the first question. You share something delightful with Alfred Nobel,

1:28.7

the father of the most famous prize on earth. I would say more people respect the Nobel Prize, especially the Peace Prize, but I actually am not as impressed by some of the Peace Prize

1:33.8

winners as I am by you and other scientists. What binds you to Alfred Nobel? Talk about what the two of

1:41.9

you have in common, besides the prize that is upon immensely named after him.

1:46.2

Well, I think the thing that we have both in common is that, you know, he was noted for many things.

1:52.5

He had 175 patents, I think.

1:55.4

One of them was for dynamite because he used nitroglycerin as the active explosive in dynamite, which made nitroglycerin

2:03.6

actually a very safe explosive to use. And I never used nitroglycerin in terms of an explosive,

2:11.3

but when I was young, I started to use ordinary gunpowder to make explosives. And for the first

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