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Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Fluticasone Nasal Pharmacology

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5716 Ratings

🗓️ 3 February 2022

⏱️ 12 minutes

🧾️ Download transcript

Summary

Fluticasone (Flonase) is a nasal corticosteroid that is used in the management of allergic rhinitis.



A primary adverse effect that I have seen in practice with fluticasone is the risk for nose bleeds.



Flonase can have some interactions via CYP3A4. Inhibitors of CYP3A4 like clarithromycin can increase concentrations.



While the risk for systemic exposure is low with nasal fluticasone, long-term, high dose, and frequent use should be monitored appropriately.

Transcript

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0:00.0

Hey all, welcome back to the Real Life Pharmacology podcast. I'm your host pharmacist, Eric

0:05.1

Christensen. Thank you so much for listening today. As always, you can track me down on LinkedIn,

0:10.2

Eric Christensen, FarmD, Bcpsps, BcGP. Feel free to go ahead and connect with me there. Go check out

0:18.3

real life pharmacology.com. Find the subscribe button there and we will email you a

0:24.0

free 31 page PDF on the top 200 drugs. It's a great study guide, great review. If you're out in

0:31.5

practice or if you're going through pharmacology exams and classes, great refresher, great review.

0:39.1

I share a lot of things that are going to show up on exams as well as things that actually show up in real life as well. So go get that at

0:45.0

real life pharmacology.com. The drug of the day today is fluticazone. And specifically I'm going to

0:52.8

hone in on the nasal spray. There's a couple of brand names specifically I'm going to hone in on the nasal spray.

0:56.3

There's a couple of brand names and different formulations.

1:00.4

Verimist is one that's Fluticazone furuate, and Flonase is the one I'm going to lean on mostly

1:07.6

here.

1:08.4

That's Fluticazone propionate.

1:15.1

Flonase is in practice, the one that I've seen much more common than other formulations, generally inexpensive. It's now available over

1:21.8

the counter as of a few years ago. So you're going to see patients using this medication for sure. Now what are they going to be

1:29.6

using it for? Primarily, you're going to see this med used for allergic rhinitis. So that's an important

1:37.4

thing to monitor, an important thing to follow. And how this medication works, as you could maybe

1:43.7

deduct from the name, Fluticazone, it is a corticosteroid.

1:49.5

So it's going to primarily reduce inflammation and also potentially give you some vasoconstriction locally in the nose as well,

2:01.3

which can help alleviate those symptoms of runny nose and irritation and sneezing, of course.

2:08.8

I do want to take the time to go through administration of nasal medications,

2:15.3

and specifically here, obviously, Flonase.

...

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