Hey all, welcome back to the real life pharmacology podcast. I am your host, pharmacist, Eric Christensen.

Thank you so much for listening today. As always, go check out the free 31-page PDF on the top 200

drugs at real-life pharmacology. A great study guide if you're in pharmacy school, med school,

nursing school going through pharmacology classes. I pull out a lot of info based upon my clinical experience as well as

based upon my experience of passing numerous board exams throughout my career. So definitely go

check that out. Just a simple email. We'll get you that 31 page PDF for free.

A great little review resource for you there.

So with that, let's get into the drug of the day today, and that is clomaphene.

Brand name of this medication is Clomid, and this drug is categorized as a serm.

So that's a selective estrogen receptor modifier.

And you may have remembered, I believe I've covered a couple of serms,

but probably the most common serms I think of in clinical practice are raloxifine and tamoxifen.

However, clomophine is definitely used for something significantly different than those two agents.

Tamoxifen being typically breast cancer, reloxifine can be used for osteoporosis.

So clomophine is actually used to help stimulate ovulation.

So we're primarily looking at female infertility and things of that nature.

So mechanistically, how does it do that?

Well, being a CERM, you can expect that it's going to mess with estrogen receptors in some capacity.

So it binds estrogen receptors, and Clomophene actually hangs onto those receptors

or stays coupled to those receptors for a longer period of time than estrogen does.

And if you remember in the body thinking about using birth control, that's using estrogen to essentially reduce the risk of pregnancy by binding to those estrogen receptors longer.

It kind of messes up that normal estrogen negative feedback, which ultimately prevents ovulation.

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