Fixing fat bubbles for vaccines, and preventing pain from turning chronic

Science Magazine Podcast

Science Podcast

News, News Commentary, Science

4.3 • 842 Ratings

🗓️ 12 May 2022

⏱️ 30 minutes

🔗️ Recording | iTunes | RSS

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Summary

On this week’s show: Lipid nanoparticles served us well as tiny taxis delivering millions of mRNA vaccines against COVID-19, but they aren’t optimized—yet, and why we might need inflammation to stop chronic pain The messenger RNA payload of the mRNA vaccines against SARS-CoV-2 is wrapped up in little fatty packets called lipid nanoparticles (LNPs). These fat bubbles were originally designed for something much different—carrying molecules into cells to silence genes. But they were useful and we were in a hurry, so not much was changed about them when they were pressed into service against COVID-19. Science journalist Elie Dolgin talks with host Sarah Crespi about ongoing efforts to improve LNPs as a delivery system for mRNA vaccines and therapeutic treatments. Next on the show, we hear about “pain chronification.” Have you ever thought about chronic pain? What happens in the body when it heals—no specific thing is broken—but the pain never subsides? Sarah chats with Luda Diatchenko, professor on the faculties of medicine and dentistry at McGill University, about her Science Translational Medicine paper on the need for inflammation to prevent pain chronification. This week’s episode was produced with help from Podigy. [Image: V. Altounian/Science; Music: Jeffrey Cook] [alt: lipid nanoparticle illustration with podcast symbol overlay] Authors: Sarah Crespi; Elie Dolgin Episode page: https://www.science.org/doi/10.1126/science.adc9455 About the Science Podcast: https://www.science.org/content/page/about-science-podcast Learn more about your ad choices. Visit megaphone.fm/adchoices

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0:00.0	This podcast is supported by the Icon School of Medicine at Mount Sinai, one of America's leading research medical schools.
0:07.8	Icon Mount Sinai is the academic arm of the eight hospital Mount Sinai health system in New York City.
0:13.9	It's consistently among the top recipients of NIH funding.
0:18.0	Researchers at Icon Mount Sinai have made breakthrough discoveries in many fields vital to
0:23.0	advancing the health of patients, including cancer, COVID and long COVID, cardiology, neuroscience, and
0:30.4	artificial intelligence. The Icon School of Medicine at Mount Sinai, we find a way. Morgan State
0:37.3	University, a Baltimore, Maryland,
0:39.4	Carnegie R2 doctoral research institution, offers more than 100 academic programs and awards
0:45.4	degrees at the baccalaureate, master's, and doctoral levels, is furthering their mission of
0:50.4	growing the future leading the world. Morgan continues to address the needs and challenges of the modern urban environment.
0:57.4	With a four-year quadrupling of research, more than a dozen new doctoral programs,
1:02.4	and eight new national centers of excellence, Morgan is positioned to achieve Carnegie R1
1:07.8	designation in the next five years.
1:10.4	To learn more about Morgan and their
1:12.3	ascension to R1, visit Morgan.edu slash research. This is the science podcast for May 13th,
1:25.3	2022. I'm Sarah Crespi. Each week we talk about the most interesting
1:29.5	news and research for science and the sister journals. First up, freelance science journalist
1:35.1	Ailey Dolgan. He wrote this week in science about lipid nanoparticles. These are those little
1:40.4	fat bubbles that surround the mRNANA in MRNA vaccines.
1:44.5	We talk about what these particles were originally designed for and what can be done now
1:49.3	to optimize them for vaccines and therapeutics.
1:52.7	Next is researcher Luda Diachenko.
	...

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