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Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Erythromycin Pharmacology

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5716 Ratings

🗓️ 17 October 2019

⏱️ 12 minutes

🧾️ Download transcript

Summary

Erythromycin uniquely has some potential benefit in the setting of gastroparesis. Azithromycin you will likely not see used for this indication.



Erythromycin binds the 50s subunit and ultimately prevents protein synthesis which is necessary for bacteria to grow and replicate.



QTc prolongation is a risk with all macrolide antibiotics (erythromycin included).



By inhibiting CYP3A4, erythromycin can be responsible for numerous drug interactions.

Transcript

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0:00.0

Hey all, welcome back to the real-life pharmacology podcast.

0:03.6

I'm your host, pharmacist Eric Christensen.

0:07.2

Thanks so much for listening all the kind words, comments, ratings, reviews on iTunes.

0:12.1

It's greatly appreciated.

0:13.7

If you haven't done so and you enjoy the podcast today,

0:16.9

I appreciate you taking the time to consider doing that.

0:20.3

So I like to get into it. So we're going to get into erythromycin today.

0:25.4

And this is a macrolide antibiotic, and in clinical practice, this medication isn't used terribly often,

0:34.9

but there is some really important things that you need to know if you ever do see

0:40.5

a patient on it. So definitely some important drug interactions and things like that to look out for.

0:46.9

And I'll cover that more in more detail, of course, in the drug interactions section.

0:52.4

But first, you know, kind of with the mechanism and the way the drug works, it is classified

0:58.1

as a macrolide antibiotic.

1:00.6

I know there's tendencies for young pharmacists and students in school and in pharmacology

1:07.1

trying to memorize endings and things of that nature.

1:10.8

So erythromycin is not going to be in the same class. Marmacology trying to memorize endings and things of that nature.

1:16.2

So erythromycin is not going to be in the same class as vancomycin.

1:19.5

It is not in the same class as gentimicin.

1:25.9

So there is that temptation to try to memorize those endings, and it can be helpful in some ways, but in some ways it could lead you astray.

1:29.4

So you can go back and listen to the podcast on azithromycin, but I'll spare you that.

1:34.8

The mechanism, simply put, it binds the 50s ribosomal subunit, and within bacteria,

1:43.6

what this does is this actually blocks the production of essential

...

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