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The Science of Everything Podcast

Episode 154: Magnetic Resonance Imaging

The Science of Everything Podcast

James Fodor

Social Sciences, Natural Sciences, Science

4.8819 Ratings

🗓️ 23 September 2025

⏱️ 92 minutes

🧾️ Download transcript

Summary

An overview of Magnetic Resonance Imaging (MRI), beginning from the basic physics of nuclear magnetic resonance, and covering the use of radiowaves to excite nuclear spin states, and the T1 and T2 modes of relaxation. We then explore how these phenomena are used to produce 3d images, including magnetic field gradients, frequency encoding, phase encoding, and Fourier transforms. We conclude with a discussion of functional imaging, including the haemodynamic response, the BOLD signal, echo planar imaging, and the steps of preprocesing. Recommended pre-listening is Episode 14: Principles of Quantum Mechanics, and Episode 61: Magnetism. If you enjoyed the podcast please consider supporting the show by making a PayPal donation or becoming a Patreon supporter. https://www.patreon.com/jamesfodor https://www.paypal.me/ScienceofEverything

Transcript

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0:00.0

Oh, wow, oh, oh, whoa, oh, wow.

0:13.0

Oh, wow.

0:15.0

Oh, Jane. Hello, you're listening to The Science of Everything podcast, episode 154, Magnetic Resonance Imaging.

0:40.8

I'm your host, James Fodor.

0:42.7

So today we're going to talk about MRI or magnetic resonance imaging.

0:47.6

We're going to cover the physics behind it, including how the excitation, the magnetic excitation occurs in the nucleus, how magnetic gradients are used to encode spatial information about the image.

0:59.5

We're going to talk about how the image is reconstructed, the computational techniques underpinning that, and we're also going to compare how structural versus functional imaging works and explain the differences there. And we'll conclude with

1:13.2

a bit of a discussion about post-processing of functional imaging data. So this is a topic that's been

1:19.4

requested a few times, I think, and is a particularly sort of interesting and tricky area that I don't

1:25.2

think very well understood. So I think it should be an interesting episode. Recommended pre-listening is episode 14 principles of quantum mechanics and episode

1:33.5

61 on magnetism. So without further ado, let's get started and we'll begin by talking about

1:39.8

nuclear magnetic resonance. MRI stands for magnetic resonance imaging. It's a medical imaging technique,

1:46.2

which is also used in science, scientific research, which is able to generate pictures of the

1:52.5

anatomy and physiological processes within the body. What makes MRI unique is that it's able to

1:59.1

generate high-resolution images of soft tissue within the body,

2:04.3

so without needing to cut open any parts of the body. So it's non-invasive. It differs from other

2:10.0

imaging modalities like CT or x-rays, which are primarily only useful for imaging hard tissues of the body like bones, for example.

2:20.3

It also has much higher resolution than other imaging modalities like PET scans or ultrasound.

2:26.3

Because of this, MRI has attracted a lot of interest over the years, both from researchers and the public.

2:32.3

The name of the technique, magnetic resonance imaging,

2:36.1

has actually been changed. Originally it was called nuclear magnetic resonance imaging because

2:41.3

that's the technique that it actually uses, but the nuclear was removed from the name because

...

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