Today, we have the second episode of a two-part mashup series focused on weight-loss resistance.  For today’s episode, I am delighted to welcome experts Dr. Mary Claire Haver, Dr. Rocio Salas-Whalen, and Physician’s Assistant McCall McPherson.  Dr. Haver and I explore how inflammation drives weight gain and unpack specific strategies for macronutrients, meal timing, and more. Dr. Salas-Whalen and I examine body composition changes during perimenopause and menopause, our family responsibilities, the importance of strength training for maintaining muscle mass, and the targeted use of GLP-1 agonist drugs. Finally, McCall and I break down the labs that help guide decision-making, also discussing informed consent, the effects of hormonal replenishment therapy (now known as personalized endocrine treatment), the strategic use of GLP-1s, personalized dosages, and microdosing. This mashup includes many timely and relevant insights from three experts at the forefront of women’s health. Join us as we explore the science, strategies, and solutions shaping the future of weight loss resistance. IN THIS EPISODE, YOU WILL LEARN: How slowing sugar absorption reduces insulin spikes and inflammation The value of combining healthy fats, complex carbs, and lean protein at every meal  Why spreading protein intake throughout the day is crucial for metabolism, hormone regulation, and muscle preservation How prioritizing self-care and modeling it for children helps break the cycle of parental over-sacrifice Why strength training is more effective than cardio for long-term body composition and metabolic health The mounting stress, family pressures, and reduced self-care that many women face in their 40s and 50s How synthetic hormones in oral contraceptives disrupt thyroid, testosterone, and reproductive hormones How GLP-1 agonists can improve weight loss, food freedom, and metabolic flexibility How supporting adrenal health enhances energy, balances hormones, and improves metabolic flexibility Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to support@cynthiathurlow.com Join other like-minded women in a supportive, nurturing community (The Midlife Pause/Cynthia Thurlow)  Cynthia’s Menopause Gut Book is on presale now! Cynthia’s Intermittent Fasting Transformation Book The Midlife Pause supplement line Connect with Dr. Mary Claire Haver On her website Instagram and TikTok The Galveston Diet Book Ep. 308 Weight Gain in Middle Age, Perimenopause and Inflammation with Mary Claire Haver Connect with Dr. Rocio Salas-Whalen On her website Instagram Ep. 384 Why Weight Loss is Complex: Obesity’s Multi-Factorial Nature with Dr. Rocio Salas-Whalen Connect with McCall McPherson Modern Thyroid Clinic On Instagram and TikTok Modern Thyroid and Wellness Podcast Thyroid Lab Guide Ep. 282 Thyroid Health: Hormones, Medications & Weight Loss with McCall McPherson