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Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+

Ep. 502 Why Ovarian Cancer Is So Hard to Diagnose – Inside the Complex World of Gynecologic Oncology with Rachel Frankenthal, PA-C

Everyday Wellness: Midlife Hormones, Menopause, and Science for Women 35+

Cynthia Thurlow

Alternative Health, Nutrition, Science, Life Sciences, Health & Fitness

4.81K Ratings

🗓️ 20 September 2025

⏱️ 54 minutes

🧾️ Download transcript

Summary

Today, I am honored to connect with Rachel Frankenthal, a board-certified physician assistant with a master's degree in public health, specializing in gynecologic oncology. Rachel is on the staff at UCLA Health, where she treats women with gynecologic cancers and women at high risk for uterine or ovarian cancer due to genetic mutations or a strong family history.  In our discussion, we unpack GYN oncology, covering the five GYN cancers, why ovarian cancer is the silent killer, and the labs and ultrasounds to help screen for ovarian cancer. We dive into genetics, including BRCA mutations and Lynch syndrome, appropriate genetic counseling, and what Rachel considers when dealing with younger patients still at peak fertility versus older patients. We explore the importance of HRT utilization for cancer previvors, the effects of pelvic radiation, vaginal and sexual health, and what thriving looks like after cancer. Rachel shares her stepwise approach to hot flashes, and we also discuss the importance of lifestyle, bone health, and specific research on the benefits of GLP-1s for women with ovarian and endometrial cancer.  This conversation is especially relevant as we are in GYN and Ovarian Cancer Awareness Month. I look forward to having Rachel back again, hopefully later this fall, to discuss the use of hormone replacement therapy with GYN oncology survivors. IN THIS EPISODE, YOU WILL LEARN: How the lack of effective screening makes ovarian cancer hard to detect due to  How BRCA and Lynch syndrome influence cancer risk and treatment choices The benefits of HRT for cancer previvors Risks that arise from surgical menopause without sufficient or properly dosed HRT Why less than 50% of eligible women actually receive hormone therapy How pelvic radiation impacts menopause, vaginal tissue, bladder, and GI health The support that is crucial for cancer survivors after pelvic radiation Lifestyle factors to improve cancer treatment outcomes   Rachel shares her stepwise approach to managing hot flashes  What GLP-1 research reveals about reducing ovarian cancer mortality and endometrial cancer risk Bio: Rachel Frankenthal Rachel Frankenthal is a board-certified and licensed Physician Associate and Menopause Society Certified Practitioner with a Master's in Public Health. She specializes in gynecologic oncology, treating women with gynecologic cancers as well as women at high risk for uterine or ovarian cancer due to genetic mutations. Rachel has a special passion for menopause and midlife women's healthcare. She developed the menopause clinic for gynecologic cancer survivors and previvors at UCLA and has played an integral role in developing the GYN cancer survivorship program, where she teaches the weekly yoga and meditation class. Rachel lectures at UCLA and across the country on the importance of comprehensive menopause care in cancer survivorship and has created a course on hormone therapy for gynecologic cancer survivors through the Heather Hirsch Academy. In addition to being a medical practitioner, Rachel is a certified yoga and Pilates instructor, a prior Broadway performer, and an advocate for integrative, holistic health. Connect with Cynthia Thurlow   Follow on X, Instagram & LinkedIn Check out Cynthia’s website Submit your questions to [email protected] Connect with Rachel Frankenthal On Instagram

Transcript

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0:00.0

Welcome to Everyday Wellness Podcast.

0:03.7

I'm your host, nurse practitioner, Cynthia Thurlow.

0:07.4

This podcast is designed to educate, empower, and inspire you to achieve your health and wellness goals.

0:13.9

My goal and intent is to provide you with the best content and conversations from leaders in the health and wellness industry each week and impact

0:22.1

over a million lives.

0:29.1

Today I had the honor of connecting with friend and colleague Rachel Frankenthal.

0:33.9

She's a board certified physician's assistant with a master's in public health.

0:38.4

She specializes in gynecologic oncology and treats women with gynecologic cancers,

0:43.2

as well as women at high risk for uterine or ovarian cancer due to genetic mutations

0:47.6

or a strong family history.

0:49.8

She's on staff at UCLA Health.

0:52.4

And today I had the honor of talking to her about what comprises

0:56.7

GYN oncology, the five GYN cancers, why ovarian cancer is the silent killer, specific

1:03.6

labs and ultrasounds that can be utilized to help screen for ovarian cancers, the impact of genetics,

1:10.7

including Brackca mutations and Lynch

1:12.9

syndrome, as well as appropriate genetic counseling, considerations that she thinks about when

1:18.8

she's dealing with younger patients, still at peak fertility versus older patients, why HRT

1:24.9

utilization is very important for the previvors. The impact of pelvic radiation, especially

1:30.8

to vaginal and sexual health, what gap she sees in survivorship, and what thriving looks like after

1:37.1

cancer, her stepwise approach to hot flashes, the impact of lifestyle, as well as bone health, and last but not least, specific

1:46.3

research to GLP1 utilization with ovarian and endometrial cancers and its impact on mortality.

1:53.6

This is a particularly important conversation, especially because this is GYN Awareness Month,

...

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