Ep. 202 - The New Supplement Everyone Will Be Talking About: Paraxanthine

Iron Culture

The MASS Crew

Sports & Recreation, Health & Fitness

4.8 • 827 Ratings

🗓️ 19 December 2022

⏱️ 115 minutes

🔗️ Recording | iTunes | RSS

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Summary

Mr. Benjamin Franklin Esgro has the unique honor of being our first guest in our episodes numbered in the 200’s, as well as being on for his fifth, or maybe sixth time? We aren’t sure, but we like to have the man on! I’m this episode, he’s once again crusading against potential charlatans in the supplement industry. If you remember last time, Ben joined us to discuss the lacking evidence of a mechanism of action behind turkesterone and today, he’s back to give us a dose of reality on paraxanthine. What is paraxanthine you might ask? Well if you haven’t already heard of it, it’s supposedly the next big thing in the stimulant, nootropic and pre workout world. But, while this supplement is interesting and may have specific utility, should we really expect something truly groundbreaking considering it’s a metabolite of caffeine? Join us as we ask Ben Esgro to find out.

00:00 Intro

5:41 (Re)introducing Ben to kickstart another monster episode

19:24 An overview of paraxanthine

Lelo 1986 Comparative pharmacokinetics of caffeine and its primary demethylated metabolites paraxanthine, theobromine and theophylline in man https://pubmed.ncbi.nlm.nih.gov/3756065/

Benowitz 1995 Sympathomimetic effects of paraxanthine and caffeine in humans https://pubmed.ncbi.nlm.nih.gov/8529334/

34:59 Selling the acute supplement sensation and experience

48:20 Marketing paraxanthine and comparisons with caffeine

1:03:40 Paraxanthine toxicity and bioengineering explained

1:14:55 Chasing the mythical unicorn of replacing banned supplements

1:23:17 Creating demand and producing the same subjective experience as paraxanthine?

1:32:38 Potency and derivatives of compounds

1:38:40 Dosages and densities of powdered supplements

1:43:45 What to expect from a paraxanthine supplement

1:48:38 Closing out with a (metaphorical) mic drop: the positive impact of the evidence-based lifting community

Li 2022 Self-Reported Training and Supplementation Practices Between Performance-Enhancing Drug-User Bodybuilders Compared with Natural Bodybuilders https://pubmed.ncbi.nlm.nih.gov/36165879/

Transcript

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0:00.0	Eric.
0:03.2	Omar.
0:04.2	I'm going to blame it on.
0:05.4	What can I say?
0:06.6	Ben, what's going on, man?
0:07.7	We got, is this the fifth time you've been on the podcast?
0:10.9	What is this?
0:11.2	The fourth time?
0:13.6	We're racking them up.
0:14.8	I'd say fourth or fifth, yeah.
0:16.5	And I bring you on just to make Eric jealous right now because folks in
0:22.7	in 2023 we are filming that film slash documentary featuring Werner Herzog we don't
0:28.8	have confirmation of him being there but what we do have confirmation of is that
0:33.4	Eric will be coaching his athlete at Sheffield the largest natural power lifting meat ever and Ben will be coaching his athlete at Sheffield, the largest natural powerlifting meet ever.
0:40.4	And Ben will be coaching two athletes, one of which Leah will be also in the same category,
0:48.4	up for the, what is it, $50,000, the top male and female lifters.
0:52.5	Is that around what is?
0:53.2	50,000 euros, gents?
0:54.8	What is it?
0:56.8	I think it's 25,000 euro for first.
1:00.9	But there's also individual lifts.
1:03.4	There's a lot of stuff.
	...

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