Endotoxin/LPS Is a Major Driver of Blood Clotting, Sepsis, Heart Attacks, and Strokes

Dr. Joseph Mercola - Take Control of Your Health

Briana Mercola

Health & Fitness, Health, Alternative Health

4.6 • 1.5K Ratings

🗓️ 19 November 2025

⏱️ 8 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

Endotoxin, a toxic molecule released by bacteria in your gut, enters your bloodstream and directly triggers blood clot formation — even in people with no signs of infection or heart disease
Researchers have shown that certain bacterial types, such as E. coli, are especially effective at setting off your body's clotting response, mimicking what happens during sepsis and other life-threatening events
Everyday habits that weaken your gut barrier — including eating seed oils, ultraprocessed foods, and alcohol, or living under chronic stress — make endotoxin exposure common, keeping your blood in a "primed" state to clot
Chronic, low-grade exposure to bacterial toxins links gut health to cardiovascular problems, explaining why heart attacks, strokes, and clotting disorders often strike people who appear healthy
Supporting your gut with easy-to-digest foods, antioxidants like niacinamide and vitamin E, and natural binders such as raw carrot salad or activated charcoal helps neutralize endotoxin and keep your blood flowing freely

Transcript

Click on a timestamp to play from that location

0:00.0	Are you unknowingly priming your blood to clot every day through tiny leaks from your gut that slip bacterial toxins into your bloodstream?
0:08.5	Welcome to Dr. Mercola's cellular wisdom. Stay informed with quick, easy-to-listen summaries of our latest articles, perfect for when you're on the go. No reading required.
0:18.1	Subscribe for free at Mercola.com for the latest health insights.
0:22.4	Hello and welcome to Dr. Mercola's cellular wisdom. Today we're examining how
0:27.3	endotoxin, lipopoly saccharide, or LPS, can trigger the same clotting cascades seen in sepsis,
0:35.4	and why this helps explain strokes and heart attacks
0:37.9	and people with normal test results. I'm Ethan Foster, and will keep this direct and practical.
0:43.6	I'm Alara Skye. You'll hear how researchers traced LPS from gut bacteria to rapid coagulation,
0:51.7	how everyday habits make exposure common, and which simple steps, limited to what
0:56.2	the article states, can help you lower your load and keep blood flowing smoothly.
1:01.3	Let's set the scene. Blood clots should seal wounds, not block oxygen to your brain or heart.
1:07.4	Yet clots increasingly appear in people without classic risk factors.
1:11.5	The emerging driver is endotoxin crossing a weakened gut barrier, entering your circulation,
1:17.5	and switching on clotting and inflammatory pathways long before symptoms appear.
1:22.2	The mechanistic evidence is clear.
1:25.0	A journal of biological chemistry study showed that LPS from bacteria, such as
1:30.0	E. coli, directly activates clotting proteins, triggering clot formation, even without injury.
1:38.1	One E. coli type was especially potent, kicking off a chain reaction that mirrors sepsis,
1:43.9	fast, coordinated, and dangerous when it happens inside healthy vessels.
1:48.0	The structure of LPS matters.
1:51.0	When LPS molecules cluster into small aggregates, they create highly effective docking sites for clotting proteins.
1:58.0	Single, isolated molecules do far less. That's why tiny amounts of
	...

Transcript will be available on the free plan in 21 days. Upgrade to see the full transcript now.

Previous episode | Next episode

Disclaimer: The podcast and artwork embedded on this page are from Briana Mercola, and are the property of its owner and not affiliated with or endorsed by Tapesearch.

Generated transcripts are the property of Briana Mercola and are distributed freely under the Fair Use doctrine. Transcripts generated by Tapesearch are not guaranteed to be accurate.