Welcome to the Fat Emperor podcast.

I'm your host, Ivor Cummins.

From a basic science perspective, there's an enormous amount of evidence that

suggests that this would be a very effective metabolic-based therapy.

I mean, you could go back to, you know, if you want to go way back,

you can go back to the early calorie restriction studies that show that animals are less likely to get

spontaneous tumors if you maintain them, you know, the 25% calorie restriction over time.

The ketogenic diet mimics in many ways fasting but also calorie

restriction in that it suppresses the hormone insulin. And we know no oncologist in their

right mind should question that cancer growth is tightly linked to insulin signaling,

and IGF1, which is kind of parallels insulin signaling and IGF1 which is kind of

parallels insulin signaling and mTOR and many of the other you know

energetic pathways anabolic pathways linked to insulin signaling so the

ketogenic diet works by suppressing the hormone insulin to drive the liver to make ketones.

Like that's really the driver.

So from our perspective, from a metabolic-based perspective, when you look at nutritional ketosis,

that produces a metabolic physiology that causes a suppression of the hormone insulin,

a depletion of liver glycogen stores, which is kind of needed in some way, or a decrease

in liver glycogen stores, and facilitate hepatic to facilitate the liver making

ketones and an elevation of ketone bodies which we have really put a lot of research

into investigating the effects of ketone bodies in and up themselves and ketones can reduce glycolytic flux through cancer cells.

That's been shown.

...