EFR 908: How to Use Methylene Blue Safely for Energy, Recovery & Brain Health with Dr. Scott Sherr
Ever Forward Radio with Chase Chewning
Chase Chewning
5 • 927 Ratings
🗓️ 13 November 2025
⏱️ 52 minutes
🧾️ Download transcript
Summary
In this second part of the conversation, Dr. Scott Sherr returns to unpack one of the most fascinating compounds in modern mitochondrial medicine — methylene blue. Once used as the first FDA-approved antimicrobial drug, methylene blue is now being rediscovered as a powerful mitochondrial optimizer that helps the body both produce and detoxify energy at the same time. Dr. Sherr breaks down how it enhances ATP production, improves focus, endurance, and recovery, and even helps with travel fatigue and brain fog. He explains how methylene blue works at the cellular level, why quality and dosing matter, and clears up common myths and controversies — including its relationship with nitric oxide, serotonin, and safety concerns. Whether you're an athlete, entrepreneur, or anyone seeking more consistent, sustainable energy, this episode will help you understand how to use methylene blue safely and effectively to support performance and longevity.
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00:01 What Is Methylene Blue? — A 150-year-old molecule repurposed for mitochondrial health
02:13 From Blue Jeans to Medicine — The strange evolution from textile dye to the first FDA-approved drug
04:48 How It Works — The only compound that helps your cells both make and detoxify energy
06:52 Cyanide Antidote — How methylene blue restores mitochondrial function, even in toxin exposure
09:05 Real-World Results — Patient stories of fatigue recovery and performance optimization
11:34 Who It's For — From chronic illness to high performers seeking clean energy
13:31 Performance & Recovery Benefits — Endurance, anaerobic performance, and muscle recovery
16:18 Recovering Faster, Training Harder — How methylene blue enhances oxygen use and heart rate recovery
18:20 How to Cycle It — When and how often to take methylene blue for best results
20:31 Travel & Jet Lag Protocols — How methylene blue acts like oxygen at altitude and in airplanes
23:29 Methylene Blue for the Everyday Person — Calm, clean energy without the crash
26:33 The Importance of Quality & Purity — How to identify pharmaceutical-grade methylene blue and avoid contaminants
27:57 What to Look for in a Supplement — USP grade, certificates of analysis, and testing standards
30:51 Counterfeit Supplements & Amazon Scams — Why most methylene blue products don't meet purity claims
33:54 How to Take It — Solubility, timing, and why troches work best
36:09 Stacking with Red Light Therapy — Synergy between methylene blue and photobiomodulation
39:10 Dosage Guidelines — How to titrate, start low, and find your personal sweet spot
42:08 Who Should Avoid It — Blood pressure medications, SSRIs, pregnancy, and other contraindications
43:48 Clearing Up the Controversy — Why experts disagree on nitric oxide and serotonin effects.
45:23 The Nitric Oxide Debate — How dose determines whether methylene blue helps or hinders
47:51 Blue Brain Myths & Social Media Clickbait — The truth about the "blue brain" narrative
49:30 Final Thoughts — Safe dosing, cycling, and the future of mitochondrial optimization
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Episode resources:
- Part one "The #1 Thing Killing Your Mitochondra & How to Stop it Today"
- Watch and subscribe on YouTube
- Learn more at Troscriptions.com/everforward
Transcript
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| 0:00.0 | One of the major levers that I've been able to really see huge shifts in people very quickly |
| 0:04.6 | is this crazy blue compound out there called Methylene Blue. |
| 0:08.7 | And it's an old, an old compound, but really repurposed for mitochondrial support. |
| 0:14.1 | And so Methylene Blue has been studied at these higher doses as an antimicrobial and has |
| 0:18.8 | fantastic capacity for that. |
| 0:22.5 | Why had I'm taking Methylene blue every four hours, 32 milligrams of methylene boosts every four hours and he cut his time down |
| 0:28.5 | by three hours. The following year. Wait, say that again, by three hours? By three hours, yeah. |
| 0:34.6 | A certain dosage leading up to an activity, during an activity, after activity. |
| 0:40.0 | Is it activity specific? |
| 0:41.9 | Or can I just begin to rotate it into my, let's say, my healthy habits, my key supplementation, |
| 0:48.3 | and just then go about my norm and then see and feel these benefits? |
| 0:52.6 | Think about it if you're on the performance side of things, even sort of regular day-to-day, optimize and not elite or anything like that, you're going to have more stress on various days. Sometimes that's going to be physical stress. Sometimes that's going to be cognitive stress. And that's where methylene blue can be really actually quite powerful. And you can use it for those higher and those bigger endurance days. You can do it for those bigger days at the gym in general. |
| 1:12.9 | Because we actually, I've been actually testing this with a couple of colleagues where it seems that even during anaerobic work, you can recover at a higher heart rate if you have methylene blue around. |
| 1:22.6 | Hello, my name is Dr. Scott Scher. |
| 1:23.9 | I'm the chief operating officer of transcriptions. |
| 1:26.0 | I'm an internal medicine physician and welcome to Everford Radio. |
| 1:35.6 | Please take us into this methylian blue world and walk us through. Why are people choosing to just |
| 1:40.9 | to dye their tongue blue to support longevity mitochondria? Or at least their urine, if they're not. Yeah, yeah, yeah. The thing about methylene blue is that it concentrates in the body in the urine. That's how you excrete it. And so if you do take methylene blue, you will have some blue urine. And so there was even songs about this. You'll like this back in the World War II era, |
| 2:01.8 | where in the Pacific, if you were being shipped over there, you had to take methylene blue |
| 2:05.4 | prophylactically to prevent microbial infections. And they had songs about singing blue in the |
| 2:11.3 | lew, or sorry, peeing blue in the loo. Almost got it, peeing blue in the loo. Yeah. Wow. |
| 2:16.3 | So methylene blue's been around a long time. |
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