EFR 906: The #1 Thing Killing Your Mitochondria & How to Stop it TODAY with Dr. Scott Sherr
Ever Forward Radio with Chase Chewning
Chase Chewning
5 • 927 Ratings
🗓️ 10 November 2025
⏱️ 62 minutes
🧾️ Download transcript
Summary
This episode is brought to you by Troscriptions.
Tired, drained, and ready for a change? You are not alone. In fact, 94% of Americans experience some degree of mitochondrial dysfunction that is possibly leading to unwanted symptoms such as brain fog, fatigue, weight gain, and even poor mental health. In this episode with Dr. Scott Sherr, MD you will learn how modern life has made us evolutionarily unfit for our environment, and why living in constant fight-or-flight mode leads to what he calls "the sympathetic spiral of doom." Together, we explore early warning signs of cellular decline, the link between mood and mitochondria, and practical strategies for restoring balance — from better sleep and parasympathetic recovery to optimizing nutrition and lab testing. This episode is a masterclass in understanding your body's energy systems and how to reclaim your vitality at the cellular level.
Follow Scott @drscottsherr
Follow Chase @chase_chewning
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00:01 What Is Mitochondrial Dysfunction? — 94% of U.S. adults struggle with energy and detoxification.
01:28 Meet Dr. Scott Sherr — His background in internal medicine and health optimization.
04:00 The Science of ATP — How your body creates 150 pounds of energy every day — and the hidden cost.
06:58 What's Breaking Our Mitochondria — Sugar, medications, toxins, and chronic stress.
09:28 Why We're Not Built for Modern Life — Evolutionary mismatch and constant overstimulation.
12:52 Energy Production vs. Detoxification — The "plumbing" analogy that explains cellular backup.
15:48 Early Warning Signs — Fatigue, mood swings, slow recovery, and why energy equals emotion.
20:59 You Can Feel Fine and Still Be Unhealthy — Why "not sick" doesn't mean "optimized."
24:53 Optimizing Cellular Health — Nutrient testing, heavy metals, inflammation, and resilience between ages 21–30.
27:54 The #1 Mitochondrial Killer: Stress — Why sympathetic overdrive is the hidden threat to energy.
30:41 The Sympathetic Spiral of Doom — How stress hormones shut down energy production.
35:59 Breaking the Spiral — Awareness, HRV, recovery, and restoring nervous system balance.
41:46 The Role of Safety and GABA — How feeling unsafe keeps you stuck in fight-or-flight.
46:49 Biohacks That Actually Work — GABA, sauna, sleep, and Dr. Sherr's nightly recovery ritual.
49:31 Modeling Health for the Next Generation — Mindfulness, meditation, and leading by example.
53:15 Ever Forward — Energy as currency and the art of being both present and progressing.
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Transcript
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| 0:00.0 | The following is an operation podcast production. So many people are having issues with mitochondrial |
| 0:06.4 | function. In fact, 94% of U.S. adults have some element of mitochondrial dysfunction. And what that means |
| 0:12.8 | is that they even have a hard time either making energy in the mitochondria or they have a hard time |
| 0:17.5 | detoxifying from the energy that we make. The number one reason for mitochondrial dysfunction is insulin resistance, |
| 0:23.8 | meaning people that don't have a well-optimized glucose transport system |
| 0:28.2 | because they're having too much sugar on a regular basis. |
| 0:30.5 | This is obviously diabetics, but even people that are insulin resistance, |
| 0:33.5 | and this is over three-quarters of the U.S. adults just on that side of things. |
| 0:37.8 | The key to understand here is that the cells in our body that require more energy, |
| 0:41.8 | that require more energy production are going to have more mitochondria. |
| 0:44.9 | So the number one energy production cell in the body, like the number one of the most mitochondria |
| 0:51.2 | per cell, is actually in the eggs. |
| 0:53.4 | So ovaries that produce eggs have the most mitochondria per cell. S in the eggs. So ovaries that produce eggs have |
| 0:54.8 | the most mitochondria per cell. Sperm are not far behind because we have to swim a relatively far |
| 0:59.6 | distance to go and fertilize the egg. And then you have the brain, the heart, the liver, |
| 1:04.7 | muscle skeletal tissue has a huge amount in reserve, okay, because it has to have the capacity |
| 1:09.6 | for you to make a lot of energy very quickly if you have to run away from something or run to something. Our bodies are sort of they're primed to be able to make energy when it's required, but they try to conserve it as much as possible as well. And that's going to become really important later when we talk about something called the cell danger response and how our body tries to shut down when we're under stress. |
| 1:28.7 | Hello, my name is Dr. Scott Scher. |
| 1:30.1 | I'm the chief operating officer of transcriptions. |
| 1:32.2 | I'm an internal medicine physician and welcome to Everford Radio. |
| 1:39.5 | So you are not only an MD medical doctor, but you are this expert, this authority in |
| 1:46.9 | integrative health and longevity optimization. |
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