EFR 891: Nitric Oxide Explained - Dr. Nathan Bryan on Aging, Alzheimer’s, and Performance

Ever Forward Radio with Chase Chewning

Chase Chewning

Healthcoach, Education, Self-improvement, Mental Health, Wellness, Fitness, Humanoptimization, Resiliency, Holistic, Highperformance, Coaching, Biohack, Health, Military, Entrepreneurship, Mindset, Health & Fitness

5 • 927 Ratings

🗓️ 11 August 2025

⏱️ 74 minutes

🔗️ Recording | iTunes | RSS

🧾️ Download transcript

Summary

Nitric oxide might be the most important molecule you’ve never heard of. In this episode, molecular medicine pioneer Dr. Nathan Bryan, PhD reveals how this fleeting gas controls blood flow, brain health, immune defense, and even sexual function. We cover the science of nitric oxide, how lifestyle choices impact its production, and why it could hold the key to preventing age-related diseases like Alzheimer’s. You’ll learn simple daily strategies to boost your nitric oxide naturally—without falling for supplement marketing gimmicks.

Follow Dr. Bryan @drnathansbryan

Follow Chase @chase_chewning

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In this episode we discuss...

00:00 – Introduction

01:00 – What is Nitric Oxide?

03:05 – Why Nitric Oxide is Short-Lived

05:34 – How Nitric Oxide Works

08:03 – Immune Defense & Nitric Oxide

09:50 – Symptoms of Low Nitric Oxide

15:11 – The American Lifestyle Problem

19:56 – Nitric Oxide for Performance & Recovery

24:06 – Cardiovascular Health & Longevity

26:03 – How the Body Produces Nitric Oxide

32:00 – Beetroot & Supplement Myths

34:04 – Two Steps to Boost Production

36:03 – Nasal Breathing & Humming

39:01 – Mouth Taping for Sleep & Nitric Oxide

41:52 – Oral Microbiome & Diet

44:46 – The Antacid Problem

49:40 – Variability in Vegetable Nitrate Levels

52:52 – Risks of Overproduction

54:40 – Nitrate/Nitrite Marketing Myths

58:34 – Cutting-Edge Research & Drug Development

01:03:08 – Dr. Bryan’s Daily Optimization Protocol

01:07:52 – The Mindset of Doing Hard Things

01:10:38 – Ever Forward

01:11:44 – Nitric Oxide & ALS

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Episode resources:

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Save 20% on creatine gummies with code EVERFORWARD at https://www.LegionAthletics.com
Watch and subscribe on YouTube
Get his book The Secret of Nitric Oxide

Transcript

Click on a timestamp to play from that location

0:00.0	The following is an operation podcast production.
0:03.4	Our body are designed in such an intricate way where there's always reactions and we signal,
0:08.5	we turn things on, we turn things off.
0:11.2	And our body is always adapting to a new environment.
0:14.6	But nitric oxide, once it's produced, it signals, right?
0:17.4	So it activates second messenger systems and the second messengers are a little bit
0:21.1	longer lasting and then you got endocrine function where it binds to molecules. It's transported
0:25.3	throughout the cardiovascular system. So I always say nitric oxide is like if you've got a string
0:29.7	of dominoes and that last domino is kind of like optimal life, optimal performance. And nitric oxide
0:37.2	is that first domino, right?
0:39.0	So to get to that end, all you have to do is tip over that first domino.
0:42.7	And then everything else takes care of itself.
0:44.4	And we're going to learn how to do that in a really efficient way today.
0:47.9	Everyone, Dr. Nathan, Brian here,
0:49.7	international leader in molecular medicine, nitric oxide biochemistry.
0:52.6	This is Ever Forward Radio.
1:00.4	Thank you. or later in molecular medicine, nitric oxide biochemistry. This is Everford Radio. Guys, welcome back to Everford Radio.
1:02.4	I have, by popular demand, the other man myth and legend, apparently there are a few
1:08.0	keys in the nitric oxide world.
1:10.2	By popular demand, you all just
1:11.6	raved about Dr. Nathan Bryan from my last few episodes covering nitric oxide to with Dr. Lou
1:17.5	Ignaro that are now well into the millions of views. And any other time I have a guess where we
	...

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