EFR 791: Why Aging is Not a Disease, Debunking Longevity Claims, SIRT 2 and SIRTUINS, the Benefits of NAD, and "Podcast Disease" with Dr. Charles Brenner

Ever Forward Radio with Chase Chewning

Chase Chewning

Healthcoach, Education, Self-improvement, Mental Health, Wellness, Fitness, Humanoptimization, Resiliency, Holistic, Highperformance, Coaching, Biohack, Health, Military, Entrepreneurship, Mindset, Health & Fitness

5 • 927 Ratings

🗓️ 27 March 2024

⏱️ 85 minutes

🔗️ Recording | iTunes | RSS

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Summary

Join me and my esteemed guest, Dr. Charles Brenner, PhD for a fascinating journey through the science of aging and longevity, where we explore the complexities and truths behind what it really means to age gracefully. We challenge the notion that aging is a disease and instead discuss practical strategies for maintaining our vitality—physically, mentally, and emotionally. As we debunk myths like the exaggerated benefits of resveratrol, listen in as we emphasize evidence-based insights and dismantle the disparity between scientific facts and the marketing of anti-aging remedies.

Venturing into the realm of genetics, our conversation turns to the role of sirtuins and other genes that have sparked interest in the longevity market. Both initial hype and subsequent rigorous research may temper expectations, but it reminds us of the nuanced relationship between genetic research and its implications on human aging. Moreover, we examine the essential role of NAD in metabolism and how factors like alcohol consumption can compromise this crucial coenzyme system, affecting our health and aging process.

Wrapping up, we shift our focus to practical lifestyle choices that can optimize health, such as the balance of diet and exercise, and the role of GLP-1 drugs in weight management. We highlight the impact of NAD and its precursors like NR on cellular health and DNA repair, offering insights into their supplementation and clinical applications. Don't miss this episode filled with valuable knowledge that could transform the way you think about aging and longevity - or go against the advice of your favorite podcast!

Follow Charles @charlesmbrenner

Follow Chase @chase_chewning

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In this episode we discuss...

(00:00) The Science of Aging and Longevity

(09:52) Debunking the Anti-Aging Hype

(23:04) Exploration of Longevity Genes and Sirtuins

(38:03) The Role of NAD in Metabolism

(51:04) Sun Exposure, Skin Health, & Lifestyle

(01:03:54) Optimizing Health Through Diet and Exercise

(01:14:08) NAD and NR

(01:21:19) Living Ever Forward

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Episode resources:

Save 10% on Magnesium Breakthrough with code EVERFORWARD10 at https://www.Bioptimizers.com/everforward
Save 15% on Fatty15 C:15 healthy fat supplement with code EVERFORWARD at https://www.Fatty15.com/everforward
Save 10% on any diagnostic lab with code CHASE at https://www.blokes.co/chase and https://www.choosejoi.com/chase
Watch and subscribe on YouTube
Learn more at CityOfHope.org and TruNiagen.com

Transcript

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0:00.0	The following is an operation podcast production.
0:03.2	What is the difference between longevity and anti-aging?
0:06.2	Is aging a disease?
0:07.8	Do you view those two things differently at all?
0:09.7	No.
0:10.7	No, aging is not a disease.
0:12.0	Humans are very good agers. It is a fundamental feature of life.
0:17.0	I don't think there's any evidence that there's a technology that's going to allow people to extend
0:23.0	maximum human lifespan but I do think that there are things that we can do
0:26.9	that will allow us to age better. Resveritrol is probably the you know the
0:31.5	the biggest stench it's garbage are there examples in
0:37.1	mammalian biology where single genes can extend life time yes would you want to
0:42.4	have those genes would you want to have those genes? Would you want to have your
0:45.6	growth hormone pathway inactivated? No, you would not. So Sur2 is like the founding
0:50.8	member of a gene family called Sir Toons.
0:54.4	They are not longevity genes.
0:56.1	We could summarize our conversation
0:58.3	and boil it down to one statement about NAD.
1:03.0	What would it be?
1:05.0	NADs.
1:06.0	This is Dr. Charles Brenner.
1:07.0	I'm a professor at City of Hope in Tuarte, California,
	...

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