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Science Friday

Drugs Designed By AI, The Phosphorus Paradox, Regulating PFAS Chemicals. March 17, 2023, Part 1

Science Friday

Science Friday and WNYC Studios

Natural Sciences, Science, Life Sciences, Wnyc, Friday

4.4 • 6.4K Ratings

🗓️ 17 March 2023

⏱️ 47 minutes

🧾️ Download transcript

Summary

At Long Last, More Regulations For Forever Chemicals This week, the EPA proposed the first national standards for drinking water that would set limits on the amount of PFAS (per- and polyfluoroalkyl substances) chemicals that would be allowed in water systems. There are thousands of different PFAS chemicals, which are often used industrially for properties such as heat, water and stain resistance—from fire-fighting foams to coatings on clothing and paper plates. They have come to be known as “forever chemicals” as they are extremely slow to break down in the environment. The chemicals have been linked to health problems, including cancer. Katherine Wu, staff writer for The Atlantic, joins Ira to talk about the proposed regulations and how such a sweeping rule might be implemented nationwide. Wu also discusses her latest article on COVID-19 origins, and genetic analysis that could tie the pandemic back to raccoon dogs in the Wuhan market. They also talk about other news from the week in science, including research hinting at active volcanoes on Venus, a study of the effects of COVID-19 on maternal health during pregnancy, and research into curing HIV with stem cells from cord blood. Plus an explosion of seaweed, and the unveiling of a new space suit design.   How AI Is Changing The Drug Development Pipeline Researching and developing new drugs is a notoriously long and expensive process, filled with a lot of trial and error. Before a new drug gets approved scientists must come up with something they think might work in the lab, test it in animals, and then if it passes those hurdles, clinical trials in humans. In an effort to smooth out some of the bumps along the road, a growing number of pharma companies are turning to new artificial intelligence tools in the hopes of making the process cheaper and faster. Ira talks with Will Douglas Heaven, senior editor for AI at MIT Technology Review about his reporting on the topic.    An Ambitious Plan To Build Back Louisiana’s Coast Louisiana will receive more than $2 billion to pay for an ambitious, first-of-its-kind plan to reconnect the Mississippi River to the degraded marshes on Plaquemines Parish’s west bank. A collective of federal and state agencies—the Louisiana Trustees Implementation Group—signed off on the multibillion-dollar Mid-Barataria Sediment Diversion on Wednesday. The funding will come out of settlement dollars resulting from the 2010 Deepwater Horizon oil spill. Once constructed, the two-mile-long sediment diversion is expected to build up to 27 square miles of new land by 2050. In the next 50 years, as Louisiana’s coast continues to sink and global sea levels rise, the diversion is also projected to sustain one-fifth of the remaining land. “The Trustees believe that a sediment diversion is the only way to achieve a self-sustaining marsh ecosystem in the Barataria Basin,” wrote the implementation group in its decision. Read the rest at sciencefriday.com. Balancing The Good And Bad Of Phosphorus Phosphorus is critical to life as we know it. In fact, every cell in the human body contains this important element. It’s also a key component in fertilizer. But not all of that fertilizer stays on crops—much of that phosphorus flows into waterways. Therein lies the rub: the runoff fertilizes the plant life growing in the water, creating toxic algal blooms. To top it all off, the phosphorus reserves in the United States are on track to disappear in just a few decades, according to some estimates.  Ira talks about the past, present, and future of phosphorus with Dan Egan, journalist in residence at the University of Wisconsin-Milwaukee’s School of Freshwater Sciences, and author of the new book, The Devil’s Element: Phosphorus and A World out of Balance. Want to read The Devil’s Element with us? Join the SciFri Book Club and read along!   Transcripts for each segment will be available the week after the show airs on sciencefriday.com.

Transcript

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0:00.0

This is Science Friday. I'm Iroflato. Later in the hour, how the pharma industry is using new

0:05.5

AI tools to develop new drugs faster and cheaper, plus our complicated relationship with phosphorus.

0:12.0

But first, chemical news of another sort. This week, the EPA announced that it would move to

0:18.9

tighten regulations on PFAS chemicals. Those are the so-called

0:22.7

forever chemicals that have been linked to health problems and that are turning up all over the

0:28.4

environment. Joining me now to talk about that and other stories from the week in science is

0:33.4

Catherine Wu, staff writer at the Atlantic. Welcome back. Hello, always good to be here.

0:39.5

Nice to have you. All right, how big a deal is this EPA proposal? It is a pretty big deal.

0:46.7

I mean, this is the first time that the EPA has really cracked down on PFAS, and they are going basically as low as they can. The plan, unless it is derailed,

0:57.8

is to basically say you cannot have any detectable PFS in the water from now on or at least starting

1:04.9

a few months from now if this goes through. Tell us what the chemical is all about. Why are they

1:09.8

around all these things?

1:11.4

So there's a couple things. First, if you basically check the blood of pretty much anyone,

1:16.6

you will detect some levels of these chemicals. And part of the reason is once they get out

1:21.4

into the environment, they pretty much stick around. The nickname of Forever Chemicals is pretty

1:26.0

apt because once they head out into the environment,

1:28.3

they really don't break down very well. So if they are being produced in factories and then

1:34.4

running off into the water, they will be there for quite a long time. And a lot of companies have

1:38.9

used these. These chemicals are really good at repelling oil and water. And so they're used in a lot

1:43.9

of non-stick pans, water repellent clothing, things that are really a at repelling oil and water. And so they're used in a lot of non-stick

1:44.7

pans, water repellent clothing, things that are really a big part of our everyday lives. And they

1:50.2

never go away. So what is the plan then to remove it from the water? It is going to be a massive

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