So, guys, this is Derek. Moreplace, more dates, more days.com. I wanted to do a quick

video on androgen receptor downregulation. So this is something that, you know, I used to really

wonder myself and it was hard to get an answer on about if you take anabolic

regardless if for p-ed you know performance enhancing use or for therapeutic reasons for

maintaining you know high quality of life for TRT stuff like that um does gear eventually you know

downregulate the receptor where you need to cycle off

it to resensitize the receptor in order to make it work better when you use it again so first of all

obviously this typically isn't an option for guys on TRT because they're using it to maintain

levels that they otherwise would not indogenously be able to achieve.

So sort of, you know, a bit less relevant for that particular application.

But as far as receptor downregulation, it doesn't happen.

When you train and engage in resistance training or you take, you know, performance enhancing drugs, let's just say, you know, like testosterone because that's like

the therapeutic thing that's like accepted.

It's like, you know, has medical applications.

So it's easier to talk about in like a YouTube friendly context.

When you take your TRT, do your androgen receptors upregulate? They don't downregulate.

And what happens after that point is your body actually increases myostatin to inhibit you

from gaining more muscle than you should. The mechanism by which your body is, you know,

inhibited from just gaining absurd amounts of muscle is not your androgen receptors

are becoming desensitized to the testosterone that you're using. Rather, it's your body's

endogenous production of myostatin is going up in order to counteract and prevent you from

gaining stupid amounts of muscle because the body has

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