Hey all, welcome back to the Real Life Pharmacology podcast. I am your host, pharmacist Eric Christensen,

and I thank you so much for listening today. As always, go check out Real Life Pharmacology.com.

Go subscribe there to the email list, and we'll get you a free top 200 study guide.

It's a 31-page PDF. A great refresher if you're out in practice or if you're

going through pharmacology classes as a nursing student, pharmacy student, med student,

definitely going to help you out a lot there. So again, go check out that resource. I've brought

in a lot of clinical practice pearls, things that you see show up on

board exams, as well as things that you're going to see in real life. So real life pharmacology.com,

simply an email will get you access to that. All right. So let's get into the drug of the day

today, and that is denosumab.

We've got a couple of brand names with this medication.

So first is ExGiva, which I'm not going to talk about too much here,

but that can be utilized in hypercalcemia of malignancy.

Again, kind of more of a specialized use, not something you're going to see

day-to-day in a primary care type setting. So I'm definitely going to focus more on prolea.

So this is primarily used for osteoporosis management.

And the most common situation, at least at this point,

that I see this medication utilized,

is in patients who cannot tolerate bisphosphonate. So let's take a drug bisphosphonate like lendronate, for example.

Maybe a patient can't tolerate it due to esophageal

ulceration maybe they've got you know terrible renal function things like that which may prevent the

use of a bisphosphonate might be a situation where we start to look at denosumab as a potential alternative.

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