David Sinclair: The GLP-1 Side Effect No One Talks About, What AI Found in His Lab, and Reversing Blindness | Q&A EP #251

Moonshots with Peter Diamandis

PHD Ventures

Business

4.8 • 605 Ratings

🗓️ 28 April 2026

⏱️ 27 minutes

🔗️ Recording | iTunes | RSS

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Summary

This episode was filmed at the 2026 Abundance360 Summit. Learn more at https://www.abundance360.com/ This Q&A is about longevity, and especially how David Sinclair sees AI speeding up drug discovery, biological-age reversal, and the future of healthspan. It also covers GLP-1s, telomeres, genetics, muscle preservation, hormone replacement, indoor environment, and the role of mindset in aging well. Get access to metatrends 10+ years before anyone else - https://qr.diamandis.com/metatrends Peter H. Diamandis, MD, is the Founder of XPRIZE, Singularity University, ZeroG, and A360 David A. Sinclair, A.O., Ph.D., is a tenured Professor of Genetics at Harvard Medical School and a serial biotech entrepreneur. Peter H. Diamandis, MD, is the Founder of XPRIZE, Singularity University, ZeroG, and A360 – My companies: Apply to Dave's and my new fund:https://qr.diamandis.com/linkventureslanding Go to Blitzy to book a free demo and start building today: https://qr.diamandis.com/blitzy Your body is incredibly good at hiding disease. Schedule a call with Fountain Life to add healthy decades to your life, and to learn more about their Memberships: https://www.fountainlife.com/peter _ Connect with Peter: X Instagram Substack Website Xprize Connect with David X Instagram Website Listen to MOONSHOTS: Apple YouTube – *Recorded on March 9th, 2026 *The views expressed by me and all guests are personal opinions and do not constitute Financial, Medical, or Legal advice. Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0	There's a lot to say about GLP-1s.
0:02.0	More and more data is coming out showing benefits to the heart, the brain, beyond just weight loss.
0:06.0	There is one downside that I need to point out besides what's known about risks.
0:11.0	We are working with companies and academics that do a lot of AI now.
0:16.0	It's accelerating our work exponentially.
0:19.0	AI-driven drug design and looking at billions and eventually trillions of molecules
0:23.6	to see which ones might reverse aging.
0:26.6	We've done that already.
0:27.6	And if anyone tells you AI can only do what we've taught it,
0:30.6	that is the biggest bunch of BS you'll ever hear.
0:33.6	My ancestors die in their 70s.
0:34.6	My grandmother had a stroke in her 30s. So the fact that my father is now living in a healthy way beyond any of his ancestors probably ever
0:42.3	is testament that you can really change what your genes have given you.
0:46.3	One thing that is the most powerful, your mindset.
0:49.3	I think this is the most exciting time ever to be alive.
0:51.3	I want to see as much of it as I possibly can.
0:57.1	Now that's the moonshot, ladies and gentlemen.
1:02.0	A rare opportunity here. I think we have about 25 minutes for Q&A or so. And, you know, sleep
1:08.2	and exercise. I think you and I differentiate a little bit on that because I'm like, I like sleep for me trying to get eight hours and I'm trying to be in the gym five days a week.
1:21.0	You're not as, where do you stand on sleep and exercise?
1:24.7	I would be sleeping a lot more and exercising a lot more if I wasn't traveling on an
1:30.1	airplane most of the time and in the lab. But I have a standing desk and I have a treadmill at home
	...

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