David Sinclair on the Longevity Pill, Age Reversal Timelines, and Updated Protocols | EP #250

Moonshots with Peter Diamandis

PHD Ventures

Business

4.8 • 604 Ratings

🗓️ 27 April 2026

⏱️ 33 minutes

🔗️ Recording | iTunes | RSS

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Summary

This episode was filmed at the 2026 Abundance360 Summit. Learn more at https://www.abundance360.com/ In this insightful interview, Dr. David Sinclair discusses groundbreaking advancements in longevity research, including epigenetic reprogramming trials, the potential for extending human lifespan, and accessible therapies. He shares his personal protocols and the future of anti-aging science, emphasizing the importance of innovation and community support. Get access to metatrends 10+ years before anyone else - https://qr.diamandis.com/metatrends David A. Sinclair, A.O., Ph.D., is a tenured Professor of Genetics at Harvard Medical School and a serial biotech entrepreneur. Peter H. Diamandis, MD, is the Founder of XPRIZE, Singularity University, ZeroG, and A360 – My companies: Apply to Dave's and my new fund:https://qr.diamandis.com/linkventureslanding Go to Blitzy to book a free demo and start building today: https://qr.diamandis.com/blitzy Your body is incredibly good at hiding disease. Schedule a call with Fountain Life to add healthy decades to your life, and to learn more about their Memberships: https://www.fountainlife.com/peter _ Connect with Peter: X Instagram Connect with David X Instagram Website Listen to MOONSHOTS: Apple YouTube – *Recorded on March 9th, 2026 *The views expressed by me and all guests are personal opinions and do not constitute Financial, Medical, or Legal advice. Learn more about your ad choices. Visit megaphone.fm/adchoices

Transcript

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0:00.0	This feels like another Wright Brothers moment.
0:02.0	Once you can fly, everything changes, and I think we're about to learn whether we can fly or not.
0:06.0	I'm pretty sure we can.
0:08.0	The news du jour, you are days away from the first human epigenetic reprogramming trial.
0:15.0	Three of the Yamanaka genes, a subset of them, they're going into the eye of a patient shortly to see if we can cure
0:23.2	blindness. We find that every tissue that we go into as a field, we see benefits. Brain age
0:29.1	reversal, improvement in memory, motor neurons, so ALS, the immune system, muscle, kidney,
0:35.5	mentioned liver, skin.
0:36.9	A true longevity therapeutic, when given, would work throughout the entire body.
0:41.3	And that's the objective here.
0:43.3	Is there an upper limit to how long humans can live?
0:47.3	I'm not saying that, but I am saying that.
0:50.3	Now that's the moonshot, ladies and gentlemen.
0:57.5	David, please, I grab my hot water and lemon.
1:02.3	What are you drinking?
1:03.6	Coffee.
1:04.2	Coffee, all right.
1:05.4	I couldn't find any macha.
1:07.4	Well, you know, I mean, coffee actually is good for you.
1:10.2	The studies show caffeine is, you know, I mean, coffee actually is good for you. The studies show caffeine is, you know,
1:13.3	I probably do about three cups. And I think it's also that decaffeated coffee, it's all the other
1:18.8	molecules in the cocoa in the caffeine bean. Yeah. Coffee comes in and out of fashion, but the fashion
	...

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