Clozapine for Treatment Resistant Schizophrenia

Psychiatry & Psychotherapy Podcast

David J Puder

Science, Health & Fitness, Medicine

4.8 • 1.3K Ratings

🗓️ 20 June 2019

⏱️ 55 minutes

🔗️ Recording | iTunes | RSS

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Summary

What is clozapine?

Not only is clozapine the gold standard medication for treatment-resistant schizophrenia, it is also one of the most unique drugs used in psychiatry.

It was synthesized 1958, only eight years after chlorpromazine, the first antipsychotic drug, was created. At that time, researchers tested for antipsychotic properties by taking various compounds and testing to see if lab mice developed dystonia and catalepsy. When researchers tested clozapine, they found that it did not cause dystonia, but instead made the mice sleepy. Because of this, clozapine was almost missed entirely as an antipsychotic medication. Eventually, however, clozapine was found to be more successful than other antipsychotic drugs.

By the 1970s, Austria, Germany, and Finland had produced positive data on clozapine proving its efficacy. However, clozapine was also found to have caused severe neutropenia in sixteen patients in Finland, and even caused the death of eight of those patients. For this reason, clozapine did not enter the United States until it was approved by the FDA in 1989.

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Transcript

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0:00.0	Hello and welcome to the Psychiatry and Psychotherapy podcast, with over 32,000 mental
0:14.2	professionals listening every episode.
0:17.2	Why?
0:18.2	Because we need to stick together to survive a mental health field.
0:20.8	I'm here to talk about getting rid of burnout, increasing jobs satisfaction, and feeling
0:25.5	like an expert in what you do.
0:29.7	All right, welcome back to the podcast.
0:32.9	I'm here with Dr. Michael Cummings.
0:35.4	He's been on several episodes, an episode on psychopathy, schizophrenia.
0:40.0	We did a series on psychopharmacology, the basics.
0:44.0	And today we're going to do a deep dive into clasceral clasoping.
0:47.7	It is anti-psychotic drug for treatment, resistance, schizophrenia.
0:52.3	This is going to be an episode more for the practitioner and for the serious, curious
0:59.5	listener.
1:00.5	But we're really going to go into a lot of the details.
1:02.8	We're going to talk like psychopharmacologists and, yeah, so Dr. Cummings.
1:07.8	Hi.
1:08.8	I am indeed happy to be back and also happy to talk a bit about clasoping one of the most
1:15.7	unique drugs currently in use in psychiatry.
1:21.2	It actually was almost missed as a psychiatric drug.
1:25.6	It was synthesized in 1958, only eight years after chlorpromising.
1:30.6	In the first anti-psychotic, at the time, they were testing for anti-psychotic compounds
	...

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