I'm going to wrap up this topic of Clostridium difficile today, and I just hope I speak right, because so far I've said some dumb things there.

I was at the gym, and the ladies like, hey, have a good workout. I'm like, yep, you too.

And I just feel like there are some days where no matter what you do, you are going to say the wrong thing.

It's like if you get a wedding invitation

and you can't make it, you don't want to write on it,

maybe next time.

But let's try this.

So I'm gonna start with some rather new stuff,

and this comes out of the journal JAMA surgery,

so Journal of American Medical Association surgery,

and this is from December 2018.

And this was a really interesting study that looked at peripheral eocinopinia, so low

eocinophils on admission. And if you remember in the last few lectures about this topic, I was talking about how

Clostridium difficile, the problem is it can range from very mild to very fulminate, where you're

getting a colectomy and vasopressors and even death, and is trying to determine who has a very mild

disease or maybe not even a disease if they have a false positive test,

meaning they are a carrier for clostridium difficile, but they don't have clostridium difficile

infection. So we want to try to come up with prediction models for who is at risk for mortality,

who is at risk for progressing to severe disease.

And so the reason this study was done is because previous studies looking at mouse models

have noticed that peripheral blood eocinophils are depleted in connection with binary

toxin that's produced by certain strains of

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