Clindamycin Pharmacology Podcast

Real Life Pharmacology - Pharmacology Education for Health Care Professionals

Eric Christianson, PharmD; Pharmacology Expert and Clinical Pharmacist

Education, Health & Fitness, Medicine

5 • 716 Ratings

🗓️ 20 July 2023

⏱️ 12 minutes

🔗️ Recording | iTunes | RSS

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Summary

On this podcast episode, I discuss clindamycin pharmacology, adverse effects, drug interactions, and much more!

Clindamycin (oral administration) can cause esophageal irritation and it is recommended to take this medication with a full glass of water.

C. Diff risk and frequent dosing are two of the biggest downsides to using clindamycin to manage infections.

Clindamycin has good activity against many gram-positive organisms like Staph and Strep as well as anaerobic activity.

Transcript

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0:00.0	Hey, all, welcome back to the real-life pharmacology podcast.
0:03.8	I'm your host, pharmacist, Eric Christensen.
0:06.0	Thank you so much for listening today.
0:08.3	As always, go check out our free 31-page PDF on the top 200 drugs.
0:13.7	It's a great study guide, great review if you're out in practice.
0:18.0	Simply an email is going to get you access to that.
0:20.6	So kind of a no-brainer to go get that
0:22.7	at real-life pharmacology.com. The drug of the day today is going to be clindamysin. I'm kind of
0:31.1	surprised, honestly. I haven't done this one yet, but I appreciate the podcast listener that reached out and said, hey, cover this
0:40.2	antibiotic.
0:41.3	So that's what we're going to do.
0:44.0	Brand name in this medication is Cleosin.
0:46.9	And this is classified as a lincosomide antibiotic.
0:52.0	I know there's temptation for those of you who are maybe new to pharmacology
0:57.4	to lump clindamysin in with the macrolide antibiotics, but it is not.
1:04.5	So again, the macrolides like Clarithromycin, erythromycin,
1:08.7	they are different from clindomycin for sure.
1:13.5	So mechanistically, how does this drug work?
1:17.5	It binds to the 50s ribosomal subunit, which ultimately blocks bacterial protein synthesis.
1:27.7	And if bacteria can't produce proteins and continue to function normally,
1:32.1	obviously that's going to lead to bacteria's death.
1:38.1	Indications.
	...

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