Hello, it's Jamie Lange.

And Sophie Abu, from the podcast.

Well, it's actually Sophie Lange, but that's okay.

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This is Scientific American 60 Second Science.

I'm Suzanne Bard.

Smallpox was eradicated worldwide in 1980.

So generations of people have never had to experience the devastation the disease once brought.

It could cause sometimes even an excess of 30% mortality.

It caused these very painful blisters that covered the entire body.

McMaster University's Anna Duggan.

She studies how genomes evolve. The first vaccine for

smallpox was developed in 1796. It worked by infecting people with pus from pox lesions caused by similar but far less pernicious

conditions like cow pox.

...