Hey all, welcome back to the Real Life Pharmacology podcast. I'm your host, Eric Christensen.

And today I'm going to cover Budesinide, which is a corticosteroid medication.

And I'm going to focus a little bit more specifically on Budesinide used in the GI tract.

So Budesinide has the indication for Crohn's disease,

as well as ulcerative colitis. And if you remember a little bit about these two disease states,

they are inflammatory type diseases within the GI tract.

Now, ulcerative colitis, typically we're talking about the end of the GI tract,

the colon, and that type of area.

And Crohn's disease can happen more so anywhere throughout the GI tract and the small intestine, large intestine,

as well as the colon and rectal area as well.

So that is one of the big primary differences, and certainly Budesinide can be used for that as well.

Now there are other dosage forms with budesinide.

Not going to focus on those much today,

more so with the oral and rectal formulation there.

Mechanism of action, this drug, again, is a corticosteroid, so it's going to reduce the action of

prostaglandins, of kinens, which are very, very important modulators in kind of creating

and promoting inflammation.

And in Crohn's, an ulcerative colitis,

that inflammation is a problem and can cause pain and damage

and all sorts of stuff to happen there.

Now, when using steroids virtually for anything, particularly steroids that are going to have significant systemic absorption, which Budesinide has some,

we're going to want to limit the time frame, if at all possible, of use.

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